Journal Article

DKFZ-2021-00166

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Mendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk.

Ghoneim, D. H. ; Zhu, J. ; Zheng, W. ; Long, J. ; Murff, H. J. ; Ye, F. ; Setiawan, V. W. ; Wilkens, L. R. ; Khankari, N. K. ; Haycock, P. ; Antwi, S. O. ; Yang, Y. ; Arslan, A. A. ; Beane Freeman, L. E. ; Bracci, P. M. ; Canzian, F.DKFZ* ; Du, M. ; Gallinger, S. ; Giles, G. G. ; Goodman, P. J. ; Kooperberg, C. ; Le Marchand, L. ; Neale, R. E. ; Scelo, G. ; Visvanathan, K. ; White, E. ; Albanes, D. ; Amiano, P. ; Andreotti, G. ; Babic, A. ; Bamlet, W. R. ; Berndt, S. I. ; Brais, L. K. ; Brennan, P. ; Bueno-de-Mesquita, B. ; Buring, J. E. ; Campbell, P. T. ; Rabe, K. G. ; Chanock, S. J. ; Duggal, P. ; Fuchs, C. S. ; Gaziano, J. M. ; Goggins, M. G. ; Hackert, T. ; Hassan, M. M. ; Helzlsouer, K. J. ; Holly, E. A. ; Hoover, R. N. ; Katske, V.DKFZ* ; Kurtz, R. C. ; Lee, I.-M. ; Malats, N. ; Milne, R. L. ; Murphy, N. ; Oberg, A. L. ; Porta, M. ; Rothman, N. ; Sesso, H. D. ; Silverman, D. T. ; Thompson, I. M. ; Wactawski-Wende, J. ; Wang, X. ; Wentzensen, N. ; Yu, H. ; Zeleniuch-Jacquotte, A. ; Yu, K. ; Wolpin, B. M. ; Jacobs, E. J. ; Duell, E. J. ; Risch, H. A. ; Petersen, G. M. ; Amundadottir, L. T. ; Kraft, P. ; Klein, A. P. ; Stolzenberg-Solomon, R. Z. ; Shu, X.-O. ; Wu, L.

2020
AACR Philadelphia, Pa.

This record in other databases:  

Please use a persistent id in citations: doi:10.1158/1055-9965.EPI-20-0651

Abstract: Whether circulating polyunsaturated fatty acid (PUFA) levels are associated with pancreatic cancer risk is uncertain. Mendelian randomization (MR) represents a study design using genetic instruments to better characterize the relationship between exposure and outcome.We utilized data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case-Control Consortium, involving approximately 9,269 cases and 12,530 controls of European descent, to evaluate associations between pancreatic cancer risk and genetically predicted plasma n-6 PUFA levels. Conventional MR analyses were performed using individual-level and summary-level data.Using genetic instruments, we did not find evidence of associations between genetically predicted plasma n-6 PUFA levels and pancreatic cancer risk [estimates per one SD increase in each PUFA-specific weighted genetic score using summary statistics: linoleic acid odds ratio (OR) = 1.00, 95% confidence interval (CI) = 0.98-1.02; arachidonic acid OR = 1.00, 95% CI = 0.99-1.01; and dihomo-gamma-linolenic acid OR = 0.95, 95% CI = 0.87-1.02]. The OR estimates remained virtually unchanged after adjustment for covariates, using individual-level data or summary statistics, or stratification by age and sex.Our results suggest that variations of genetically determined plasma n-6 PUFA levels are not associated with pancreatic cancer risk.These results suggest that modifying n-6 PUFA levels through food sources or supplementation may not influence risk of pancreatic cancer.

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Contributing Institute(s):

1. C055 Genomische Epidemiologie (C055)
2. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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