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000167147 1001_ $$aGhoneim, Dalia H$$b0
000167147 245__ $$aMendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk.
000167147 260__ $$aPhiladelphia, Pa.$$bAACR$$c2020
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000167147 520__ $$aWhether circulating polyunsaturated fatty acid (PUFA) levels are associated with pancreatic cancer risk is uncertain. Mendelian randomization (MR) represents a study design using genetic instruments to better characterize the relationship between exposure and outcome.We utilized data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case-Control Consortium, involving approximately 9,269 cases and 12,530 controls of European descent, to evaluate associations between pancreatic cancer risk and genetically predicted plasma n-6 PUFA levels. Conventional MR analyses were performed using individual-level and summary-level data.Using genetic instruments, we did not find evidence of associations between genetically predicted plasma n-6 PUFA levels and pancreatic cancer risk [estimates per one SD increase in each PUFA-specific weighted genetic score using summary statistics: linoleic acid odds ratio (OR) = 1.00, 95% confidence interval (CI) = 0.98-1.02; arachidonic acid OR = 1.00, 95% CI = 0.99-1.01; and dihomo-gamma-linolenic acid OR = 0.95, 95% CI = 0.87-1.02]. The OR estimates remained virtually unchanged after adjustment for covariates, using individual-level data or summary statistics, or stratification by age and sex.Our results suggest that variations of genetically determined plasma n-6 PUFA levels are not associated with pancreatic cancer risk.These results suggest that modifying n-6 PUFA levels through food sources or supplementation may not influence risk of pancreatic cancer.
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000167147 7001_ $$aZhu, Jingjing$$b1
000167147 7001_ $$aZheng, Wei$$b2
000167147 7001_ $$aLong, Jirong$$b3
000167147 7001_ $$aMurff, Harvey J$$b4
000167147 7001_ $$aYe, Fei$$b5
000167147 7001_ $$aSetiawan, Veronica Wendy$$b6
000167147 7001_ $$aWilkens, Lynne R$$b7
000167147 7001_ $$aKhankari, Nikhil K$$b8
000167147 7001_ $$00000-0001-5001-3350$$aHaycock, Philip$$b9
000167147 7001_ $$aAntwi, Samuel O$$b10
000167147 7001_ $$aYang, Yaohua$$b11
000167147 7001_ $$00000-0002-7775-8085$$aArslan, Alan A$$b12
000167147 7001_ $$aBeane Freeman, Laura E$$b13
000167147 7001_ $$aBracci, Paige M$$b14
000167147 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b15
000167147 7001_ $$aDu, Mengmeng$$b16
000167147 7001_ $$aGallinger, Steven$$b17
000167147 7001_ $$00000-0003-4946-9099$$aGiles, Graham G$$b18
000167147 7001_ $$aGoodman, Phyllis J$$b19
000167147 7001_ $$aKooperberg, Charles$$b20
000167147 7001_ $$aLe Marchand, Loïc$$b21
000167147 7001_ $$aNeale, Rachel E$$b22
000167147 7001_ $$aScelo, Ghislaine$$b23
000167147 7001_ $$00000-0002-0582-8005$$aVisvanathan, Kala$$b24
000167147 7001_ $$aWhite, Emily$$b25
000167147 7001_ $$aAlbanes, Demetrius$$b26
000167147 7001_ $$aAmiano, Pilar$$b27
000167147 7001_ $$aAndreotti, Gabriella$$b28
000167147 7001_ $$aBabic, Ana$$b29
000167147 7001_ $$00000-0003-2903-1284$$aBamlet, William R$$b30
000167147 7001_ $$aBerndt, Sonja I$$b31
000167147 7001_ $$aBrais, Lauren K$$b32
000167147 7001_ $$00000-0002-0518-8714$$aBrennan, Paul$$b33
000167147 7001_ $$aBueno-de-Mesquita, Bas$$b34
000167147 7001_ $$aBuring, Julie E$$b35
000167147 7001_ $$aCampbell, Peter T$$b36
000167147 7001_ $$00000-0002-7313-1875$$aRabe, Kari G$$b37
000167147 7001_ $$aChanock, Stephen J$$b38
000167147 7001_ $$aDuggal, Priya$$b39
000167147 7001_ $$aFuchs, Charles S$$b40
000167147 7001_ $$aGaziano, J Michael$$b41
000167147 7001_ $$aGoggins, Michael G$$b42
000167147 7001_ $$00000-0002-7012-1196$$aHackert, Thilo$$b43
000167147 7001_ $$aHassan, Manal M$$b44
000167147 7001_ $$aHelzlsouer, Kathy J$$b45
000167147 7001_ $$aHolly, Elizabeth A$$b46
000167147 7001_ $$aHoover, Robert N$$b47
000167147 7001_ $$00000-0002-6509-6555$$aKatske, Verena$$b48
000167147 7001_ $$aKurtz, Robert C$$b49
000167147 7001_ $$aLee, I-Min$$b50
000167147 7001_ $$00000-0003-2538-3784$$aMalats, Núria$$b51
000167147 7001_ $$00000-0001-5764-7268$$aMilne, Roger L$$b52
000167147 7001_ $$aMurphy, Neil$$b53
000167147 7001_ $$00000-0003-2539-9807$$aOberg, Ann L$$b54
000167147 7001_ $$aPorta, Miquel$$b55
000167147 7001_ $$aRothman, Nathaniel$$b56
000167147 7001_ $$00000-0002-9698-9954$$aSesso, Howard D$$b57
000167147 7001_ $$aSilverman, Debra T$$b58
000167147 7001_ $$aThompson, Ian M$$b59
000167147 7001_ $$00000-0003-3096-9595$$aWactawski-Wende, Jean$$b60
000167147 7001_ $$aWang, Xiaoliang$$b61
000167147 7001_ $$aWentzensen, Nicolas$$b62
000167147 7001_ $$00000-0003-3950-4815$$aYu, Herbert$$b63
000167147 7001_ $$aZeleniuch-Jacquotte, Anne$$b64
000167147 7001_ $$00000-0003-3950-4815$$aYu, Kai$$b65
000167147 7001_ $$aWolpin, Brian M$$b66
000167147 7001_ $$00000-0001-5256-0163$$aJacobs, Eric J$$b67
000167147 7001_ $$aDuell, Eric J$$b68
000167147 7001_ $$aRisch, Harvey A$$b69
000167147 7001_ $$aPetersen, Gloria M$$b70
000167147 7001_ $$00000-0003-1859-8971$$aAmundadottir, Laufey T$$b71
000167147 7001_ $$aKraft, Peter$$b72
000167147 7001_ $$00000-0003-2737-8399$$aKlein, Alison P$$b73
000167147 7001_ $$aStolzenberg-Solomon, Rachel Z$$b74
000167147 7001_ $$aShu, Xiao-Ou$$b75
000167147 7001_ $$aWu, Lang$$b76
000167147 773__ $$0PERI:(DE-600)2036781-8$$a10.1158/1055-9965.EPI-20-0651$$gVol. 29, no. 12, p. 2735 - 2739$$n12$$p2735 - 2739$$tCancer epidemiology, biomarkers & prevention$$v29$$x1538-7755$$y2020
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