TY  - JOUR
AU  - Ghoneim, Dalia H
AU  - Zhu, Jingjing
AU  - Zheng, Wei
AU  - Long, Jirong
AU  - Murff, Harvey J
AU  - Ye, Fei
AU  - Setiawan, Veronica Wendy
AU  - Wilkens, Lynne R
AU  - Khankari, Nikhil K
AU  - Haycock, Philip
AU  - Antwi, Samuel O
AU  - Yang, Yaohua
AU  - Arslan, Alan A
AU  - Beane Freeman, Laura E
AU  - Bracci, Paige M
AU  - Canzian, Federico
AU  - Du, Mengmeng
AU  - Gallinger, Steven
AU  - Giles, Graham G
AU  - Goodman, Phyllis J
AU  - Kooperberg, Charles
AU  - Le Marchand, Loïc
AU  - Neale, Rachel E
AU  - Scelo, Ghislaine
AU  - Visvanathan, Kala
AU  - White, Emily
AU  - Albanes, Demetrius
AU  - Amiano, Pilar
AU  - Andreotti, Gabriella
AU  - Babic, Ana
AU  - Bamlet, William R
AU  - Berndt, Sonja I
AU  - Brais, Lauren K
AU  - Brennan, Paul
AU  - Bueno-de-Mesquita, Bas
AU  - Buring, Julie E
AU  - Campbell, Peter T
AU  - Rabe, Kari G
AU  - Chanock, Stephen J
AU  - Duggal, Priya
AU  - Fuchs, Charles S
AU  - Gaziano, J Michael
AU  - Goggins, Michael G
AU  - Hackert, Thilo
AU  - Hassan, Manal M
AU  - Helzlsouer, Kathy J
AU  - Holly, Elizabeth A
AU  - Hoover, Robert N
AU  - Katske, Verena
AU  - Kurtz, Robert C
AU  - Lee, I-Min
AU  - Malats, Núria
AU  - Milne, Roger L
AU  - Murphy, Neil
AU  - Oberg, Ann L
AU  - Porta, Miquel
AU  - Rothman, Nathaniel
AU  - Sesso, Howard D
AU  - Silverman, Debra T
AU  - Thompson, Ian M
AU  - Wactawski-Wende, Jean
AU  - Wang, Xiaoliang
AU  - Wentzensen, Nicolas
AU  - Yu, Herbert
AU  - Zeleniuch-Jacquotte, Anne
AU  - Yu, Kai
AU  - Wolpin, Brian M
AU  - Jacobs, Eric J
AU  - Duell, Eric J
AU  - Risch, Harvey A
AU  - Petersen, Gloria M
AU  - Amundadottir, Laufey T
AU  - Kraft, Peter
AU  - Klein, Alison P
AU  - Stolzenberg-Solomon, Rachel Z
AU  - Shu, Xiao-Ou
AU  - Wu, Lang
TI  - Mendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 29
IS  - 12
SN  - 1538-7755
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2021-00166
SP  - 2735 - 2739
PY  - 2020
AB  - Whether circulating polyunsaturated fatty acid (PUFA) levels are associated with pancreatic cancer risk is uncertain. Mendelian randomization (MR) represents a study design using genetic instruments to better characterize the relationship between exposure and outcome.We utilized data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case-Control Consortium, involving approximately 9,269 cases and 12,530 controls of European descent, to evaluate associations between pancreatic cancer risk and genetically predicted plasma n-6 PUFA levels. Conventional MR analyses were performed using individual-level and summary-level data.Using genetic instruments, we did not find evidence of associations between genetically predicted plasma n-6 PUFA levels and pancreatic cancer risk [estimates per one SD increase in each PUFA-specific weighted genetic score using summary statistics: linoleic acid odds ratio (OR) = 1.00, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:32967863
C2  - pmc:PMC7710600
DO  - DOI:10.1158/1055-9965.EPI-20-0651
UR  - https://inrepo02.dkfz.de/record/167147
ER  -