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@ARTICLE{Ghoneim:167147,
      author       = {D. H. Ghoneim and J. Zhu and W. Zheng and J. Long and H. J.
                      Murff and F. Ye and V. W. Setiawan and L. R. Wilkens and N.
                      K. Khankari and P. Haycock and S. O. Antwi and Y. Yang and
                      A. A. Arslan and L. E. Beane Freeman and P. M. Bracci and F.
                      Canzian$^*$ and M. Du and S. Gallinger and G. G. Giles and
                      P. J. Goodman and C. Kooperberg and L. Le Marchand and R. E.
                      Neale and G. Scelo and K. Visvanathan and E. White and D.
                      Albanes and P. Amiano and G. Andreotti and A. Babic and W.
                      R. Bamlet and S. I. Berndt and L. K. Brais and P. Brennan
                      and B. Bueno-de-Mesquita and J. E. Buring and P. T. Campbell
                      and K. G. Rabe and S. J. Chanock and P. Duggal and C. S.
                      Fuchs and J. M. Gaziano and M. G. Goggins and T. Hackert and
                      M. M. Hassan and K. J. Helzlsouer and E. A. Holly and R. N.
                      Hoover and V. Katske$^*$ and R. C. Kurtz and I.-M. Lee and
                      N. Malats and R. L. Milne and N. Murphy and A. L. Oberg and
                      M. Porta and N. Rothman and H. D. Sesso and D. T. Silverman
                      and I. M. Thompson and J. Wactawski-Wende and X. Wang and N.
                      Wentzensen and H. Yu and A. Zeleniuch-Jacquotte and K. Yu
                      and B. M. Wolpin and E. J. Jacobs and E. J. Duell and H. A.
                      Risch and G. M. Petersen and L. T. Amundadottir and P. Kraft
                      and A. P. Klein and R. Z. Stolzenberg-Solomon and X.-O. Shu
                      and L. Wu},
      title        = {{M}endelian {R}andomization {A}nalysis of n-6
                      {P}olyunsaturated {F}atty {A}cid {L}evels and {P}ancreatic
                      {C}ancer {R}isk.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {29},
      number       = {12},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2021-00166},
      pages        = {2735 - 2739},
      year         = {2020},
      abstract     = {Whether circulating polyunsaturated fatty acid (PUFA)
                      levels are associated with pancreatic cancer risk is
                      uncertain. Mendelian randomization (MR) represents a study
                      design using genetic instruments to better characterize the
                      relationship between exposure and outcome.We utilized data
                      from genome-wide association studies within the Pancreatic
                      Cancer Cohort Consortium and Pancreatic Cancer Case-Control
                      Consortium, involving approximately 9,269 cases and 12,530
                      controls of European descent, to evaluate associations
                      between pancreatic cancer risk and genetically predicted
                      plasma n-6 PUFA levels. Conventional MR analyses were
                      performed using individual-level and summary-level
                      data.Using genetic instruments, we did not find evidence of
                      associations between genetically predicted plasma n-6 PUFA
                      levels and pancreatic cancer risk [estimates per one SD
                      increase in each PUFA-specific weighted genetic score using
                      summary statistics: linoleic acid odds ratio (OR) = 1.00,
                      $95\%$ confidence interval (CI) = 0.98-1.02; arachidonic
                      acid OR = 1.00, $95\%$ CI = 0.99-1.01; and
                      dihomo-gamma-linolenic acid OR = 0.95, $95\%$ CI =
                      0.87-1.02]. The OR estimates remained virtually unchanged
                      after adjustment for covariates, using individual-level data
                      or summary statistics, or stratification by age and sex.Our
                      results suggest that variations of genetically determined
                      plasma n-6 PUFA levels are not associated with pancreatic
                      cancer risk.These results suggest that modifying n-6 PUFA
                      levels through food sources or supplementation may not
                      influence risk of pancreatic cancer.},
      cin          = {C055 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C055-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32967863},
      pmc          = {pmc:PMC7710600},
      doi          = {10.1158/1055-9965.EPI-20-0651},
      url          = {https://inrepo02.dkfz.de/record/167147},
}