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@ARTICLE{Johnson:167224,
author = {N. Johnson and S. Maguire and A. Morra and P. M. Kapoor$^*$
and K. Tomczyk and M. E. Jones and M. J. Schoemaker and C.
Gilham and M. K. Bolla and Q. Wang and J. Dennis and T. U.
Ahearn and I. L. Andrulis and H. Anton-Culver and N. N.
Antonenkova and V. Arndt$^*$ and K. J. Aronson and A.
Augustinsson and C. Baynes and L. E. B. Freeman and M. W.
Beckmann and J. Benitez and M. Bermisheva and C. Blomqvist
and B. Boeckx and N. V. Bogdanova and S. E. Bojesen and H.
Brauch$^*$ and H. Brenner$^*$ and B. Burwinkel$^*$ and D.
Campa and F. Canzian$^*$ and J. E. Castelao and S. J.
Chanock and G. Chenevix-Trench and C. L. Clarke and D. M.
Conroy and F. J. Couch and A. Cox and S. S. Cross and K.
Czene and T. Dörk and A. H. Eliassen and C. Engel and D. G.
Evans and P. A. Fasching and J. Figueroa and G. Floris and
H. Flyger and M. Gago-Dominguez and S. M. Gapstur and M.
García-Closas and M. M. Gaudet and G. G. Giles and M. S.
Goldberg and A. González-Neira and P. Guénel and E. Hahnen
and C. A. Haiman and N. Håkansson and P. Hall and U.
Hamann$^*$ and P. A. Harrington and S. N. Hart and M. J.
Hooning and J. L. Hopper and A. Howell and D. J. Hunter and
A. Jager and A. Jakubowska and E. M. John and R. Kaaks$^*$
and R. Keeman and E. Khusnutdinova and C. M. Kitahara and
V.-M. Kosma and S. Koutros and P. Kraft and V. N. Kristensen
and A. W. Kurian and D. Lambrechts and L. Le Marchand and M.
Linet and J. Lubiński and A. Mannermaa and S. Manoukian and
S. Margolin and J. W. M. Martens and D. Mavroudis and R.
Mayes and A. Meindl and R. L. Milne and S. L. Neuhausen and
H. Nevanlinna and W. G. Newman and S. F. Nielsen and B. G.
Nordestgaard and N. Obi and A. F. Olshan and J. E. Olson and
H. Olsson and E. Orban and T.-W. Park-Simon and P.
Peterlongo and D. Plaseska-Karanfilska and K. Pylkäs and G.
Rennert and H. S. Rennert and K. J. Ruddy and E. Saloustros
and D. P. Sandler and E. J. Sawyer and R. K. Schmutzler and
C. Scott and X.-O. Shu and J. Simard and S. Smichkoska and
C. Sohn and M. C. Southey and J. J. Spinelli and J. Stone
and R. M. Tamimi and J. A. Taylor and R. A. E. M. Tollenaar
and I. Tomlinson and M. A. Troester and T. Truong and C. M.
Vachon and E. M. van Veen and S. S. Wang and C. R. Weinberg
and C. Wendt and H. Wildiers and R. Winqvist and A. Wolk and
W. Zheng and A. Ziogas and A. M. Dunning and P. D. P.
Pharoah and D. F. Easton and A. F. Howie and J. Peto and I.
Dos-Santos-Silva and A. J. Swerdlow and J. Chang-Claude$^*$
and M. K. Schmidt and N. Orr and O. Fletcher and A.-L.
Børresen-Dale and G. I. G. Alnæs and K. K. Sahlberg and L.
Ottestad and R. Kåresen and E. Schlichting and M. M. Holmen
and T. Sauer and V. Haakensen and O. Engebråten and B.
Naume and A. Fosså and C. E. Kiserud and K. V. Reinertsen
and Å. Helland and M. Riis and J. Geisler and D. D. L.
Bowtell and A. deFazio and P. M. Webb and G. Chenevix-Trench
and C. Clarke and D. Marsh and R. Scott and R. Baxter and D.
Yip and J. Carpenter and A. Davis and N. Pathmanathan and P.
Simpson and D. Graham and M. Sachchithananthan and D. Amor
and L. Andrews and Y. Antill and R. Balleine and J. Beesley
and I. Bennett and M. Bogwitz and L. Botes and M. Brennan
and M. Brown and M. Buckley and J. Burke and P. Butow and L.
Caldon and I. Campbell and D. Chauhan and M. Chauhan and G.
Chenevix-Trench and A. Christian and P. Cohen and A. Colley
and A. Crook and J. Cui and M. Cummings and S.-J. Dawson and
A. DeFazio and M. Delatycki and R. Dickson and J. Dixon and
T. Edkins and S. Edwards and G. Farshid and A. Fellows and
G. Fenton and M. Field and J. Flanagan and P. Fong and L.
Forrest and S. Fox and J. French and M. Friedlander and C.
Gaff and M. Gattas and P. George and S. Greening and M.
Harris and S. Hart and N. Hayward and J. Hopper and C.
Hoskins and C. Hunt and P. James and M. Jenkins and A. Kidd
and J. Kirk and J. Koehler and J. Kollias and S. Lakhani and
M. Lawrence and G. Lindeman and L. Lipton and L. Lobb and G.
Mann and D. Marsh and S. A. McLachlan and B. Meiser and R.
Milne and S. Nightingale and S. O'Connell and S. O'Sullivan
and D. G. Ortega and N. Pachter and B. Patterson and A.
Pearn and K. Phillips and E. Pieper and E. Rickard and B.
Robinson and M. Saleh and E. Salisbury and C. Saunders and
J. Saunus and R. Scott and C. Scott and A. Sexton and A.
Shelling and P. Simpson and M. Southey and A. Spurdle and J.
Taylor and R. Taylor and H. Thorne and A. Trainer and K.
Tucker and J. Visvader and L. Walker and R. Williams and I.
Winship and M. A. Young},
collaboration = {NBCS Collaborators and A. Group and A. Investigators and k.
Investigators},
title = {{CYP}3{A}7*1{C} allele: linking premenopausal oestrone and
progesterone levels with risk of hormone receptor-positive
breast cancers.},
journal = {British journal of cancer},
volume = {124},
number = {4},
issn = {1532-1827},
address = {Edinburgh},
publisher = {Nature Publ. Group},
reportid = {DKFZ-2021-00209},
pages = {842-854},
year = {2021},
note = {2021 Feb;124(4):842-854},
abstract = {Epidemiological studies provide strong evidence for a role
of endogenous sex hormones in the aetiology of breast
cancer. The aim of this analysis was to identify genetic
variants that are associated with urinary sex-hormone levels
and breast cancer risk.We carried out a genome-wide
association study of urinary oestrone-3-glucuronide and
pregnanediol-3-glucuronide levels in 560 premenopausal
women, with additional analysis of progesterone levels in
298 premenopausal women. To test for the association with
breast cancer risk, we carried out follow-up genotyping in
90,916 cases and 89,893 controls from the Breast Cancer
Association Consortium. All women were of European
ancestry.For pregnanediol-3-glucuronide, there were no
genome-wide significant associations; for
oestrone-3-glucuronide, we identified a single peak mapping
to the CYP3A locus, annotated by rs45446698. The minor
rs45446698-C allele was associated with lower
oestrone-3-glucuronide $(-49.2\%,$ $95\%$ CI $-56.1\%$ to
$-41.1\%,$ P = 3.1 × 10-18); in follow-up analyses,
rs45446698-C was also associated with lower progesterone
$(-26.7\%,$ $95\%$ CI $-39.4\%$ to $-11.6\%,$ P = 0.001) and
reduced risk of oestrogen and progesterone receptor-positive
breast cancer (OR = 0.86, $95\%$ CI 0.82-0.91, P = 6.9 ×
10-8).The CYP3A7*1C allele is associated with reduced risk
of hormone receptor-positive breast cancer possibly mediated
via an effect on the metabolism of endogenous sex hormones
in premenopausal women.},
cin = {C071 / C020 / C070 / C120 / HD01 / C080 / C055 / B072 /
B070},
ddc = {610},
cid = {I:(DE-He78)C071-20160331 / I:(DE-He78)C020-20160331 /
I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
I:(DE-He78)HD01-20160331 / I:(DE-He78)C080-20160331 /
I:(DE-He78)C055-20160331 / I:(DE-He78)B072-20160331 /
I:(DE-He78)B070-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:33495599},
doi = {10.1038/s41416-020-01185-w},
url = {https://inrepo02.dkfz.de/record/167224},
}