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000167339 0247_ $$2ISSN$$a0020-7136
000167339 0247_ $$2ISSN$$a1097-0215
000167339 0247_ $$2doi$$adoi: 10.1002/ijc.33475.
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000167339 1001_ $$aCorradi, Chiara$$b0
000167339 245__ $$aGenome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility.
000167339 260__ $$aBognor Regis$$bWiley-Liss$$c2021
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000167339 500__ $$a2021 Jun 1;148(11):2779-2788
000167339 520__ $$aPancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability has been unexplored so far. Combining genome wide association studies and functional data, we investigated the genetic variability in all lncRNAs. We analyzed 9893 PDAC cases and 9969 controls and identified a genome-wide significant association between the rs7046076 SNP and risk of developing PDAC (P = 9.73 × 10-9 ). This SNP is located in the NONHSAG053086.2 (lnc-SMC2-1) gene and the risk allele is predicted to disrupt the binding of the lncRNA with the micro-RNA (miRNA) hsa-mir-1256 that regulates several genes involved in cell cycle, such as CDKN2B. The CDKN2B region is pleiotropic and its genetic variants have been associated with several human diseases, possibly though an imperfect interaction between lncRNA and miRNA. We present a novel PDAC risk locus, supported by a genome-wide statistical significance and a plausible biological mechanism.
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000167339 650_7 $$2Other$$aassociation study
000167339 650_7 $$2Other$$along noncoding RNA
000167339 650_7 $$2Other$$apancreatic cancer
000167339 650_7 $$2Other$$asingle nucleotide polymorphism
000167339 7001_ $$aGentiluomo, Manuel$$b1
000167339 7001_ $$aGajdán, László$$b2
000167339 7001_ $$aCavestro, Giulia Martina$$b3
000167339 7001_ $$aKreivenaite, Edita$$b4
000167339 7001_ $$aDi Franco, Gregorio$$b5
000167339 7001_ $$aSperti, Cosimo$$b6
000167339 7001_ $$aGiaccherini, Matteo$$b7
000167339 7001_ $$aPetrone, Maria Chiara$$b8
000167339 7001_ $$00000-0002-8831-7349$$aTavano, Francesca$$b9
000167339 7001_ $$aGioffreda, Domenica$$b10
000167339 7001_ $$aMorelli, Luca$$b11
000167339 7001_ $$00000-0002-4294-6799$$aSoucek, Pavel$$b12
000167339 7001_ $$aAndriulli, Angelo$$b13
000167339 7001_ $$aIzbicki, Jakob R$$b14
000167339 7001_ $$aNapoli, Niccolò$$b15
000167339 7001_ $$aMałecka-Panas, Ewa$$b16
000167339 7001_ $$aHegyi, Péter$$b17
000167339 7001_ $$aNeoptolemos, John P$$b18
000167339 7001_ $$aLandi, Stefano$$b19
000167339 7001_ $$aVashist, Yogesh$$b20
000167339 7001_ $$aPasquali, Claudio$$b21
000167339 7001_ $$0P:(DE-He78)ebb819874e9553d89bd480e6811dc0f3$$aLu, Ye$$b22$$udkfz
000167339 7001_ $$aCervena, Klara$$b23
000167339 7001_ $$aTheodoropoulos, George E$$b24
000167339 7001_ $$aMoz, Stefania$$b25
000167339 7001_ $$aCapurso, Gabriele$$b26
000167339 7001_ $$aStrobel, Oliver$$b27
000167339 7001_ $$aCarrara, Silvia$$b28
000167339 7001_ $$aHackert, Thilo$$b29
000167339 7001_ $$aHlavac, Viktor$$b30
000167339 7001_ $$aArchibugi, Livia$$b31
000167339 7001_ $$aOliverius, Martin$$b32
000167339 7001_ $$aVanella, Giuseppe$$b33
000167339 7001_ $$aVodicka, Pavel$$b34
000167339 7001_ $$aArcidiacono, Paolo Giorgio$$b35
000167339 7001_ $$aPezzilli, Raffaele$$b36
000167339 7001_ $$aMilanetto, Anna Caterina$$b37
000167339 7001_ $$aLawlor, Rita T$$b38
000167339 7001_ $$aIvanauskas, Audrius$$b39
000167339 7001_ $$aSzentesi, Andrea$$b40
000167339 7001_ $$aKupcinskas, Juozas$$b41
000167339 7001_ $$aTestoni, Sabrina G G$$b42
000167339 7001_ $$aLovecek, Martin$$b43
000167339 7001_ $$aNentwich, Michael$$b44
000167339 7001_ $$00000-0002-3295-6811$$aGazouli, Maria$$b45
000167339 7001_ $$aLuchini, Claudio$$b46
000167339 7001_ $$aZuppardo, Raffaella Alessia$$b47
000167339 7001_ $$aDarvasi, Erika$$b48
000167339 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b49$$udkfz
000167339 7001_ $$aGheorghe, Cristian$$b50
000167339 7001_ $$aJamroziak, Krzysztof$$b51
000167339 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b52$$udkfz
000167339 7001_ $$00000-0003-3220-9944$$aCampa, Daniele$$b53
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