Journal Article

DKFZ-2021-00286

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility.

Corradi, C. ; Gentiluomo, M. ; Gajdán, L. ; Cavestro, G. M. ; Kreivenaite, E. ; Di Franco, G. ; Sperti, C. ; Giaccherini, M. ; Petrone, M. C. ; Tavano, F. ; Gioffreda, D. ; Morelli, L. ; Soucek, P. ; Andriulli, A. ; Izbicki, J. R. ; Napoli, N. ; Małecka-Panas, E. ; Hegyi, P. ; Neoptolemos, J. P. ; Landi, S. ; Vashist, Y. ; Pasquali, C. ; Lu, Y.DKFZ* ; Cervena, K. ; Theodoropoulos, G. E. ; Moz, S. ; Capurso, G. ; Strobel, O. ; Carrara, S. ; Hackert, T. ; Hlavac, V. ; Archibugi, L. ; Oliverius, M. ; Vanella, G. ; Vodicka, P. ; Arcidiacono, P. G. ; Pezzilli, R. ; Milanetto, A. C. ; Lawlor, R. T. ; Ivanauskas, A. ; Szentesi, A. ; Kupcinskas, J. ; Testoni, S. G. G. ; Lovecek, M. ; Nentwich, M. ; Gazouli, M. ; Luchini, C. ; Zuppardo, R. A. ; Darvasi, E. ; Brenner, H.DKFZ* ; Gheorghe, C. ; Jamroziak, K. ; Canzian, F.DKFZ* ; Campa, D.

2021
Wiley-Liss Bognor Regis

This record in other databases:

Please use a persistent id in citations: doi:doi: 10.1002/ijc.33475.

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability has been unexplored so far. Combining genome wide association studies and functional data, we investigated the genetic variability in all lncRNAs. We analyzed 9893 PDAC cases and 9969 controls and identified a genome-wide significant association between the rs7046076 SNP and risk of developing PDAC (P = 9.73 × 10-9 ). This SNP is located in the NONHSAG053086.2 (lnc-SMC2-1) gene and the risk allele is predicted to disrupt the binding of the lncRNA with the micro-RNA (miRNA) hsa-mir-1256 that regulates several genes involved in cell cycle, such as CDKN2B. The CDKN2B region is pleiotropic and its genetic variants have been associated with several human diseases, possibly though an imperfect interaction between lncRNA and miRNA. We present a novel PDAC risk locus, supported by a genome-wide statistical significance and a plausible biological mechanism.

Keyword(s): association study ; long noncoding RNA ; pancreatic cancer ; single nucleotide polymorphism

Note: 2021 Jun 1;148(11):2779-2788

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Contributing Institute(s):

1. C055 Genomische Epidemiologie (C055)
2. C070 Klinische Epidemiologie und Alternf. (C070)
3. Präventive Onkologie (C120)
4. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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