% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Corradi:167339,
      author       = {C. Corradi and M. Gentiluomo and L. Gajdán and G. M.
                      Cavestro and E. Kreivenaite and G. Di Franco and C. Sperti
                      and M. Giaccherini and M. C. Petrone and F. Tavano and D.
                      Gioffreda and L. Morelli and P. Soucek and A. Andriulli and
                      J. R. Izbicki and N. Napoli and E. Małecka-Panas and P.
                      Hegyi and J. P. Neoptolemos and S. Landi and Y. Vashist and
                      C. Pasquali and Y. Lu$^*$ and K. Cervena and G. E.
                      Theodoropoulos and S. Moz and G. Capurso and O. Strobel and
                      S. Carrara and T. Hackert and V. Hlavac and L. Archibugi and
                      M. Oliverius and G. Vanella and P. Vodicka and P. G.
                      Arcidiacono and R. Pezzilli and A. C. Milanetto and R. T.
                      Lawlor and A. Ivanauskas and A. Szentesi and J. Kupcinskas
                      and S. G. G. Testoni and M. Lovecek and M. Nentwich and M.
                      Gazouli and C. Luchini and R. A. Zuppardo and E. Darvasi and
                      H. Brenner$^*$ and C. Gheorghe and K. Jamroziak and F.
                      Canzian$^*$ and D. Campa},
      title        = {{G}enome-wide scan of long noncoding {RNA} single
                      nucleotide polymorphisms and pancreatic cancer
                      susceptibility.},
      journal      = {International journal of cancer},
      volume       = {148},
      number       = {11},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2021-00286},
      pages        = {2779-2788},
      year         = {2021},
      note         = {2021 Jun 1;148(11):2779-2788},
      abstract     = {Pancreatic ductal adenocarcinoma (PDAC) is projected to
                      become the second cancer-related cause of death by 2030.
                      Identifying novel risk factors, including genetic risk loci,
                      could be instrumental in risk stratification and
                      implementation of prevention strategies. Long noncoding RNAs
                      (lncRNAs) are involved in regulation of key biological
                      processes, and the possible role of their genetic
                      variability has been unexplored so far. Combining genome
                      wide association studies and functional data, we
                      investigated the genetic variability in all lncRNAs. We
                      analyzed 9893 PDAC cases and 9969 controls and identified a
                      genome-wide significant association between the rs7046076
                      SNP and risk of developing PDAC (P = 9.73 × 10-9 ). This
                      SNP is located in the NONHSAG053086.2 (lnc-SMC2-1) gene and
                      the risk allele is predicted to disrupt the binding of the
                      lncRNA with the micro-RNA (miRNA) hsa-mir-1256 that
                      regulates several genes involved in cell cycle, such as
                      CDKN2B. The CDKN2B region is pleiotropic and its genetic
                      variants have been associated with several human diseases,
                      possibly though an imperfect interaction between lncRNA and
                      miRNA. We present a novel PDAC risk locus, supported by a
                      genome-wide statistical significance and a plausible
                      biological mechanism.},
      keywords     = {association study (Other) / long noncoding RNA (Other) /
                      pancreatic cancer (Other) / single nucleotide polymorphism
                      (Other)},
      cin          = {C055 / C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C055-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33534179},
      doi          = {10.1002/ijc.33475.},
      url          = {https://inrepo02.dkfz.de/record/167339},
}