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@ARTICLE{Jayasekara:167373,
      author       = {H. Jayasekara and R. J. MacInnis and L. L. Barroso and
                      A.-L. Mayen-Chacon and A. J. Cross and B. Wallner and D.
                      Palli and F. Ricceri and V. Pala and S. Panico and R. Tumino
                      and T. Kühn$^*$ and R. Kaaks$^*$ and K. Tsilidis and M.-J.
                      Sánchez and P. Amiano and E. Ardanaz and M. D. C. López
                      and S. Merino and J. A. Rothwell and M.-C. Boutron-Ruault
                      and G. Severi and H. Sternby and E. Sonestedt and B.
                      Bueno-de-Mesquita and H. Boeing and R. Travis and T. M.
                      Sandanger and A. Trichopoulou and A. Karakatsani and E.
                      Peppa and A. Tjønneland and Y. Yang and A. M. Hodge and H.
                      Mitchell and A. Haydon and R. Room and J. L. Hopper and E.
                      Weiderpass and M. J. Gunter and E. Riboli and G. G. Giles
                      and R. L. Milne and A. Agudo and D. R. English and P.
                      Ferrari},
      title        = {{L}ifetime alcohol intake, drinking patterns over time, and
                      risk of stomach cancer: a pooled analysis of data from two
                      prospective cohort studies.},
      journal      = {International journal of cancer},
      volume       = {148},
      number       = {11},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2021-00317},
      pages        = {2759-2773},
      year         = {2021},
      note         = {148(11):2759-2773},
      abstract     = {Alcohol consumption is causally linked to several cancers
                      but the evidence for stomach cancer is inconclusive. In our
                      study, the association between long-term alcohol intake and
                      risk of stomach cancer and its subtypes was evaluated. We
                      performed a pooled analysis of data collected at baseline
                      from 491,714 participants in the European Prospective
                      Investigation into Cancer and Nutrition and the Melbourne
                      Collaborative Cohort Study. Hazard ratios (HR) and $95\%$
                      confidence intervals (CI) were estimated for incident
                      stomach cancer in relation to lifetime alcohol intake and
                      group-based life course intake trajectories, adjusted for
                      potential confounders including Helicobacter pylori
                      infection. 1,225 incident stomach cancers $(78\%$
                      non-cardia) were diagnosed over 7,094,637 person-years; 984
                      in 382,957 study participants with lifetime alcohol intake
                      data (5,455,507 person-years). Although lifetime alcohol
                      intake was not associated with overall stomach cancer risk,
                      we observed a weak positive association with non-cardia
                      cancer (HR=1.03, $95\%$ CI: 1.00-1.06 per 10 g/day
                      increment), with a HR of 1.50 $(95\%$ CI: 1.08-2.09) for
                      ≥60 g/day compared with 0.1-4.9 g/day. A weak inverse
                      association with cardia cancer (HR=0.93, $95\%$ CI:
                      0.87-1.00) was also observed. HRs of 1.48 $(95\%$ CI:
                      1.10-1.99) for non-cardia and 0.51 $(95\%$ CI: 0.26-1.03)
                      for cardia cancer were observed for a life course trajectory
                      characterized by heavy decreasing intake compared with light
                      stable intake (phomogeneity =0.02). These associations did
                      not differ appreciably by smoking or Helicobacter pylori
                      infection status. Limiting alcohol use during lifetime,
                      particularly avoiding heavy use during early adulthood,
                      might help prevent non-cardia stomach cancer. Heterogeneous
                      associations observed for cardia and non-cardia cancers may
                      indicate etiologic differences.},
      keywords     = {EPIC (Other) / Lifetime alcohol intake (Other) / MCCS
                      (Other) / cardia cancer (Other) / non-cardia cancer (Other)
                      / stomach cancer (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33554339},
      doi          = {10.1002/ijc.33504},
      url          = {https://inrepo02.dkfz.de/record/167373},
}