Journal Article

DKFZ-2021-00317

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies.

Jayasekara, H. ; MacInnis, R. J. ; Barroso, L. L. ; Mayen-Chacon, A.-L. ; Cross, A. J. ; Wallner, B. ; Palli, D. ; Ricceri, F. ; Pala, V. ; Panico, S. ; Tumino, R. ; Kühn, T.DKFZ* ; Kaaks, R.DKFZ* ; Tsilidis, K. ; Sánchez, M.-J. ; Amiano, P. ; Ardanaz, E. ; López, M. D. C. ; Merino, S. ; Rothwell, J. A. ; Boutron-Ruault, M.-C. ; Severi, G. ; Sternby, H. ; Sonestedt, E. ; Bueno-de-Mesquita, B. ; Boeing, H. ; Travis, R. ; Sandanger, T. M. ; Trichopoulou, A. ; Karakatsani, A. ; Peppa, E. ; Tjønneland, A. ; Yang, Y. ; Hodge, A. M. ; Mitchell, H. ; Haydon, A. ; Room, R. ; Hopper, J. L. ; Weiderpass, E. ; Gunter, M. J. ; Riboli, E. ; Giles, G. G. ; Milne, R. L. ; Agudo, A. ; English, D. R. ; Ferrari, P.

2021
Wiley-Liss Bognor Regis

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/ijc.33504

Abstract: Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491,714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. 1,225 incident stomach cancers (78% non-cardia) were diagnosed over 7,094,637 person-years; 984 in 382,957 study participants with lifetime alcohol intake data (5,455,507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with non-cardia cancer (HR=1.03, 95% CI: 1.00-1.06 per 10 g/day increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/day compared with 0.1-4.9 g/day. A weak inverse association with cardia cancer (HR=0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for non-cardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared with light stable intake (phomogeneity =0.02). These associations did not differ appreciably by smoking or Helicobacter pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent non-cardia stomach cancer. Heterogeneous associations observed for cardia and non-cardia cancers may indicate etiologic differences.

Keyword(s): EPIC ; Lifetime alcohol intake ; MCCS ; cardia cancer ; non-cardia cancer ; stomach cancer

Note: 148(11):2759-2773

---

Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

---

Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---