001     167373
005     20240229133538.0
024 7 _ |a 10.1002/ijc.33504
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024 7 _ |a 1097-0215
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037 _ _ |a DKFZ-2021-00317
041 _ _ |a eng
082 _ _ |a 610
100 1 _ |a Jayasekara, Harindra
|0 0000-0002-2453-0183
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245 _ _ |a Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies.
260 _ _ |a Bognor Regis
|c 2021
|b Wiley-Liss
336 7 _ |a article
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500 _ _ |a 148(11):2759-2773
520 _ _ |a Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491,714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. 1,225 incident stomach cancers (78% non-cardia) were diagnosed over 7,094,637 person-years; 984 in 382,957 study participants with lifetime alcohol intake data (5,455,507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with non-cardia cancer (HR=1.03, 95% CI: 1.00-1.06 per 10 g/day increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/day compared with 0.1-4.9 g/day. A weak inverse association with cardia cancer (HR=0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for non-cardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared with light stable intake (phomogeneity =0.02). These associations did not differ appreciably by smoking or Helicobacter pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent non-cardia stomach cancer. Heterogeneous associations observed for cardia and non-cardia cancers may indicate etiologic differences.
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650 _ 7 |a EPIC
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650 _ 7 |a Lifetime alcohol intake
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650 _ 7 |a MCCS
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650 _ 7 |a cardia cancer
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650 _ 7 |a non-cardia cancer
|2 Other
650 _ 7 |a stomach cancer
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700 1 _ |a MacInnis, Robert J
|b 1
700 1 _ |a Barroso, Leila Lujan
|b 2
700 1 _ |a Mayen-Chacon, Ana-Lucia
|b 3
700 1 _ |a Cross, Amanda J
|b 4
700 1 _ |a Wallner, Bengt
|b 5
700 1 _ |a Palli, Domenico
|0 0000-0002-5558-2437
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700 1 _ |a Ricceri, Fulvio
|0 0000-0001-8749-9737
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700 1 _ |a Pala, Valeria
|b 8
700 1 _ |a Panico, Salvatore
|b 9
700 1 _ |a Tumino, Rosario
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700 1 _ |a Kühn, Tilman
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700 1 _ |a Kaaks, Rudolf
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700 1 _ |a Tsilidis, Kostas
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700 1 _ |a Sánchez, Maria-Jose
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700 1 _ |a Amiano, Pilar
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700 1 _ |a Ardanaz, Eva
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700 1 _ |a López, María Dolores Chirlaque
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700 1 _ |a Merino, Susana
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700 1 _ |a Rothwell, Joseph A
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700 1 _ |a Boutron-Ruault, Marie-Christine
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700 1 _ |a Severi, Gianluca
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700 1 _ |a Sternby, Hanna
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700 1 _ |a Sonestedt, Emily
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700 1 _ |a Bueno-de-Mesquita, Bas
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700 1 _ |a Boeing, Heiner
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700 1 _ |a Travis, Ruth
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700 1 _ |a Sandanger, Torkjel M
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700 1 _ |a Trichopoulou, Antonia
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700 1 _ |a Karakatsani, Anna
|b 29
700 1 _ |a Peppa, Eleni
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700 1 _ |a Tjønneland, Anne
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700 1 _ |a Yang, Yi
|b 32
700 1 _ |a Hodge, Allison M
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700 1 _ |a Mitchell, Hazel
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700 1 _ |a Haydon, Andrew
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700 1 _ |a Room, Robin
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700 1 _ |a Hopper, John L
|b 37
700 1 _ |a Weiderpass, Elisabete
|0 0000-0003-2237-0128
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700 1 _ |a Gunter, Marc J
|b 39
700 1 _ |a Riboli, Elio
|b 40
700 1 _ |a Giles, Graham G
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700 1 _ |a Milne, Roger L
|b 42
700 1 _ |a Agudo, Antonio
|b 43
700 1 _ |a English, Dallas R
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700 1 _ |a Ferrari, Pietro
|0 0000-0001-9358-7338
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773 _ _ |a 10.1002/ijc.33504
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Marc 21