Home > Publications database > Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies. > print |
001 | 167373 | ||
005 | 20240229133538.0 | ||
024 | 7 | _ | |a 10.1002/ijc.33504 |2 doi |
024 | 7 | _ | |a pmid:33554339 |2 pmid |
024 | 7 | _ | |a 0020-7136 |2 ISSN |
024 | 7 | _ | |a 1097-0215 |2 ISSN |
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037 | _ | _ | |a DKFZ-2021-00317 |
041 | _ | _ | |a eng |
082 | _ | _ | |a 610 |
100 | 1 | _ | |a Jayasekara, Harindra |0 0000-0002-2453-0183 |b 0 |
245 | _ | _ | |a Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies. |
260 | _ | _ | |a Bognor Regis |c 2021 |b Wiley-Liss |
336 | 7 | _ | |a article |2 DRIVER |
336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1625044124_11425 |2 PUB:(DE-HGF) |
336 | 7 | _ | |a ARTICLE |2 BibTeX |
336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
500 | _ | _ | |a 148(11):2759-2773 |
520 | _ | _ | |a Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491,714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. 1,225 incident stomach cancers (78% non-cardia) were diagnosed over 7,094,637 person-years; 984 in 382,957 study participants with lifetime alcohol intake data (5,455,507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with non-cardia cancer (HR=1.03, 95% CI: 1.00-1.06 per 10 g/day increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/day compared with 0.1-4.9 g/day. A weak inverse association with cardia cancer (HR=0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for non-cardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared with light stable intake (phomogeneity =0.02). These associations did not differ appreciably by smoking or Helicobacter pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent non-cardia stomach cancer. Heterogeneous associations observed for cardia and non-cardia cancers may indicate etiologic differences. |
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588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
650 | _ | 7 | |a EPIC |2 Other |
650 | _ | 7 | |a Lifetime alcohol intake |2 Other |
650 | _ | 7 | |a MCCS |2 Other |
650 | _ | 7 | |a cardia cancer |2 Other |
650 | _ | 7 | |a non-cardia cancer |2 Other |
650 | _ | 7 | |a stomach cancer |2 Other |
700 | 1 | _ | |a MacInnis, Robert J |b 1 |
700 | 1 | _ | |a Barroso, Leila Lujan |b 2 |
700 | 1 | _ | |a Mayen-Chacon, Ana-Lucia |b 3 |
700 | 1 | _ | |a Cross, Amanda J |b 4 |
700 | 1 | _ | |a Wallner, Bengt |b 5 |
700 | 1 | _ | |a Palli, Domenico |0 0000-0002-5558-2437 |b 6 |
700 | 1 | _ | |a Ricceri, Fulvio |0 0000-0001-8749-9737 |b 7 |
700 | 1 | _ | |a Pala, Valeria |b 8 |
700 | 1 | _ | |a Panico, Salvatore |b 9 |
700 | 1 | _ | |a Tumino, Rosario |b 10 |
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700 | 1 | _ | |a Kaaks, Rudolf |0 P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a |b 12 |u dkfz |
700 | 1 | _ | |a Tsilidis, Kostas |0 0000-0002-8452-8472 |b 13 |
700 | 1 | _ | |a Sánchez, Maria-Jose |b 14 |
700 | 1 | _ | |a Amiano, Pilar |b 15 |
700 | 1 | _ | |a Ardanaz, Eva |b 16 |
700 | 1 | _ | |a López, María Dolores Chirlaque |b 17 |
700 | 1 | _ | |a Merino, Susana |b 18 |
700 | 1 | _ | |a Rothwell, Joseph A |b 19 |
700 | 1 | _ | |a Boutron-Ruault, Marie-Christine |0 0000-0002-5956-5693 |b 20 |
700 | 1 | _ | |a Severi, Gianluca |b 21 |
700 | 1 | _ | |a Sternby, Hanna |b 22 |
700 | 1 | _ | |a Sonestedt, Emily |b 23 |
700 | 1 | _ | |a Bueno-de-Mesquita, Bas |b 24 |
700 | 1 | _ | |a Boeing, Heiner |b 25 |
700 | 1 | _ | |a Travis, Ruth |b 26 |
700 | 1 | _ | |a Sandanger, Torkjel M |b 27 |
700 | 1 | _ | |a Trichopoulou, Antonia |b 28 |
700 | 1 | _ | |a Karakatsani, Anna |b 29 |
700 | 1 | _ | |a Peppa, Eleni |b 30 |
700 | 1 | _ | |a Tjønneland, Anne |b 31 |
700 | 1 | _ | |a Yang, Yi |b 32 |
700 | 1 | _ | |a Hodge, Allison M |0 0000-0001-5464-2197 |b 33 |
700 | 1 | _ | |a Mitchell, Hazel |b 34 |
700 | 1 | _ | |a Haydon, Andrew |b 35 |
700 | 1 | _ | |a Room, Robin |b 36 |
700 | 1 | _ | |a Hopper, John L |b 37 |
700 | 1 | _ | |a Weiderpass, Elisabete |0 0000-0003-2237-0128 |b 38 |
700 | 1 | _ | |a Gunter, Marc J |b 39 |
700 | 1 | _ | |a Riboli, Elio |b 40 |
700 | 1 | _ | |a Giles, Graham G |b 41 |
700 | 1 | _ | |a Milne, Roger L |b 42 |
700 | 1 | _ | |a Agudo, Antonio |b 43 |
700 | 1 | _ | |a English, Dallas R |b 44 |
700 | 1 | _ | |a Ferrari, Pietro |0 0000-0001-9358-7338 |b 45 |
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