TY  - JOUR
AU  - Wedekind, Roland
AU  - Keski-Rahkonen, Pekka
AU  - Robinot, Nivonirina
AU  - Viallon, Vivian
AU  - Rothwell, Joseph A
AU  - Boutron-Ruault, Marie-Christine
AU  - Aleksandrova, Krasimira
AU  - Wittenbecher, Clemens
AU  - Schulze, Matthias B
AU  - Halkjaer, Jytte
AU  - Rostgaard-Hansen, Agnetha Linn
AU  - Kaaks, Rudolf
AU  - Katzke, Verena
AU  - Masala, Giovanna
AU  - Tumino, Rosario
AU  - de Magistris, Maria Santucci
AU  - Krogh, Vittorio
AU  - Sacerdote, Carlotta
AU  - Jakszyn, Paula
AU  - Weiderpass, Elisabete
AU  - Gunter, Marc J
AU  - Huybrechts, Inge
AU  - Scalbert, Augustin
TI  - Pepper Alkaloids and Processed Meat Intake: Results From a randomized Trial and the EUROPEAN Prospective Investigation on Cancer and Nutrition (EPIC) Cohort.
JO  - Molecular nutrition & food research
VL  - 65
IS  - 7
SN  - 1613-4125
CY  - Weinheim
PB  - Wiley-VCH
M1  - DKFZ-2021-00380
SP  - e2001141
PY  - 2021
N1  - 2021 Apr;65(7):e2001141
AB  - Processed meat intake has been associated with adverse health outcomes. However, little is known about the type of processed meat more particularly responsible for these effects. This study aims to identify novel biomarkers for processed meat intake.In a controlled randomized cross-over dietary intervention study, 12 healthy volunteers consumed different processed and non-processed meats for 3 consecutive days each. Metabolomics analyses were applied on post-intervention fasting blood and urine samples to identify discriminating molecular features of processed meat intake. Nine and five pepper alkaloid metabolites, including piperine, were identified as major discriminants of salami intake in urine and plasma, respectively. This article is protected by copyright. All rights reserved CONCLUSION: Pepper alkaloids are major discriminants of intake for sausages which contain high levels of pepper used as ingredient. Further work is needed to assess if pepper alkaloids in combination with other metabolites may serve as biomarkers of processed meat intake.
KW  - Biomarkers of intake (Other)
KW  - metabolomics (Other)
KW  - pepper alkaloids (Other)
KW  - piperine (Other)
KW  - processed meat (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33592132
DO  - DOI:10.1002/mnfr.202001141.
UR  - https://inrepo02.dkfz.de/record/167479
ER  -