Journal Article

DKFZ-2021-00380

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Pepper Alkaloids and Processed Meat Intake: Results From a randomized Trial and the EUROPEAN Prospective Investigation on Cancer and Nutrition (EPIC) Cohort.

Wedekind, R. ; Keski-Rahkonen, P. ; Robinot, N. ; Viallon, V. ; Rothwell, J. A. ; Boutron-Ruault, M.-C. ; Aleksandrova, K. ; Wittenbecher, C. ; Schulze, M. B. ; Halkjaer, J. ; Rostgaard-Hansen, A. L. ; Kaaks, R.DKFZ* ; Katzke, V.DKFZ* ; Masala, G. ; Tumino, R. ; de Magistris, M. S. ; Krogh, V. ; Sacerdote, C. ; Jakszyn, P. ; Weiderpass, E. ; Gunter, M. J. ; Huybrechts, I. ; Scalbert, A.

2021
Wiley-VCH Weinheim

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Please use a persistent id in citations: doi:doi: 10.1002/mnfr.202001141.   doi:doi: 10.1002/mnfr.202001141.

Abstract: Processed meat intake has been associated with adverse health outcomes. However, little is known about the type of processed meat more particularly responsible for these effects. This study aims to identify novel biomarkers for processed meat intake.In a controlled randomized cross-over dietary intervention study, 12 healthy volunteers consumed different processed and non-processed meats for 3 consecutive days each. Metabolomics analyses were applied on post-intervention fasting blood and urine samples to identify discriminating molecular features of processed meat intake. Nine and five pepper alkaloid metabolites, including piperine, were identified as major discriminants of salami intake in urine and plasma, respectively. This article is protected by copyright. All rights reserved CONCLUSION: Pepper alkaloids are major discriminants of intake for sausages which contain high levels of pepper used as ingredient. Further work is needed to assess if pepper alkaloids in combination with other metabolites may serve as biomarkers of processed meat intake.

Keyword(s): Biomarkers of intake ; metabolomics ; pepper alkaloids ; piperine ; processed meat

Note: 2021 Apr;65(7):e2001141

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; DEAL Wiley ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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