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@ARTICLE{Wedekind:167479,
      author       = {R. Wedekind and P. Keski-Rahkonen and N. Robinot and V.
                      Viallon and J. A. Rothwell and M.-C. Boutron-Ruault and K.
                      Aleksandrova and C. Wittenbecher and M. B. Schulze and J.
                      Halkjaer and A. L. Rostgaard-Hansen and R. Kaaks$^*$ and V.
                      Katzke$^*$ and G. Masala and R. Tumino and M. S. de
                      Magistris and V. Krogh and C. Sacerdote and P. Jakszyn and
                      E. Weiderpass and M. J. Gunter and I. Huybrechts and A.
                      Scalbert},
      title        = {{P}epper {A}lkaloids and {P}rocessed {M}eat {I}ntake:
                      {R}esults {F}rom a randomized {T}rial and the {EUROPEAN}
                      {P}rospective {I}nvestigation on {C}ancer and {N}utrition
                      ({EPIC}) {C}ohort.},
      journal      = {Molecular nutrition $\&$ food research},
      volume       = {65},
      number       = {7},
      issn         = {1613-4125},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {DKFZ-2021-00380},
      pages        = {e2001141},
      year         = {2021},
      note         = {2021 Apr;65(7):e2001141},
      abstract     = {Processed meat intake has been associated with adverse
                      health outcomes. However, little is known about the type of
                      processed meat more particularly responsible for these
                      effects. This study aims to identify novel biomarkers for
                      processed meat intake.In a controlled randomized cross-over
                      dietary intervention study, 12 healthy volunteers consumed
                      different processed and non-processed meats for 3
                      consecutive days each. Metabolomics analyses were applied on
                      post-intervention fasting blood and urine samples to
                      identify discriminating molecular features of processed meat
                      intake. Nine and five pepper alkaloid metabolites, including
                      piperine, were identified as major discriminants of salami
                      intake in urine and plasma, respectively. This article is
                      protected by copyright. All rights reserved CONCLUSION:
                      Pepper alkaloids are major discriminants of intake for
                      sausages which contain high levels of pepper used as
                      ingredient. Further work is needed to assess if pepper
                      alkaloids in combination with other metabolites may serve as
                      biomarkers of processed meat intake.},
      keywords     = {Biomarkers of intake (Other) / metabolomics (Other) /
                      pepper alkaloids (Other) / piperine (Other) / processed meat
                      (Other)},
      cin          = {C020},
      ddc          = {540},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33592132},
      doi          = {10.1002/mnfr.202001141.},
      url          = {https://inrepo02.dkfz.de/record/167479},
}