000167577 001__ 167577
000167577 005__ 20240229133543.0
000167577 0247_ $$2doi$$a10.1002/dad2.12151
000167577 0247_ $$2pmid$$apmid:33614887
000167577 0247_ $$2pmc$$apmc:PMC7875190
000167577 0247_ $$2altmetric$$aaltmetric:100369904
000167577 037__ $$aDKFZ-2021-00442
000167577 041__ $$aeng
000167577 082__ $$a610
000167577 1001_ $$0P:(DE-He78)6cc3cc35505b446fde081e7cd89a4b87$$aMöllers, Tobias$$b0$$eFirst author$$udkfz
000167577 245__ $$aAβ misfolding in blood plasma measured by immuno-infrared-sensor as an age-independent risk marker of Alzheimer's disease.
000167577 260__ $$aHoboken, NJ$$bWiley$$c2021
000167577 3367_ $$2DRIVER$$aarticle
000167577 3367_ $$2DataCite$$aOutput Types/Journal article
000167577 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1637227627_29527
000167577 3367_ $$2BibTeX$$aARTICLE
000167577 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000167577 3367_ $$00$$2EndNote$$aJournal Article
000167577 500__ $$a#EA:C070#LA:C070#
000167577 520__ $$aDetermining potential risk factors of amyloid beta (Aβ) misfolding in blood, a risk marker for clinical Alzheimer's disease (AD), could have important implications for its utility in future research and clinical settings.Participants aged 50 to 75 years attending a general health examination were recruited for a prospective community-based cohort study in Saarland, Germany, in 2000 to 2002. For these analyses, participants with available Aβ misfolding measurements and clinical AD information at 17-year follow-up were included (n = 444).Age did not show any association with Aβ misfolding in plasma; however, a strong association of both age and Aβ misfolding with the incidence of clinical AD was evident. Education and cardiovascular diseases were likewise not associated with Aβ misfolding.Structural measurement of Aβ misfolding in blood plasma is an age-independent risk marker of clinical AD among older adults, supporting that risk of clinical AD is already largely determined before older adulthood.
000167577 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000167577 588__ $$aDataset connected to CrossRef, PubMed,
000167577 650_7 $$2Other$$aAlzheimer's disease
000167577 650_7 $$2Other$$aage
000167577 650_7 $$2Other$$aamyloid beta misfolding
000167577 650_7 $$2Other$$acohort study
000167577 650_7 $$2Other$$arisk factors
000167577 7001_ $$0P:(DE-He78)104fae0755c89365b7ae32238b3f1f52$$aStocker, Hannah$$b1$$udkfz
000167577 7001_ $$0P:(DE-He78)d9d72431035d8535d1b65ce9a01c2f60$$aPerna, Laura$$b2$$udkfz
000167577 7001_ $$aNabers, Andreas$$b3
000167577 7001_ $$aRujescu, Dan$$b4
000167577 7001_ $$aHartmann, Annette M$$b5
000167577 7001_ $$aHolleczek, Bernd$$b6
000167577 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b7$$udkfz
000167577 7001_ $$aGerwert, Klaus$$b8
000167577 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b9$$eLast author$$udkfz
000167577 773__ $$0PERI:(DE-600)2832898-X$$a10.1002/dad2.12151$$gVol. 13, no. 1$$n1$$pe12151$$tAlzheimer's & dementia / Diagnosis, assessment & disease monitoring$$v13$$x2352-8729$$y2021
000167577 909CO $$ooai:inrepo02.dkfz.de:167577$$pVDB
000167577 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6cc3cc35505b446fde081e7cd89a4b87$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000167577 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)104fae0755c89365b7ae32238b3f1f52$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000167577 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d9d72431035d8535d1b65ce9a01c2f60$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000167577 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aDeutsches Krebsforschungszentrum$$b7$$kDKFZ
000167577 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000167577 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000167577 9130_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000167577 9141_ $$y2021
000167577 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2020-09-09
000167577 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-09-09
000167577 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2020-09-09
000167577 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2020-09-09
000167577 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2020-09-09
000167577 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2020-09-09
000167577 915__ $$0LIC:(DE-HGF)CCBYNCNDNV$$2V:(DE-HGF)$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND (No Version)$$bDOAJ$$d2020-09-09
000167577 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2020-09-09
000167577 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2020-09-09
000167577 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000167577 980__ $$ajournal
000167577 980__ $$aVDB
000167577 980__ $$aI:(DE-He78)C070-20160331
000167577 980__ $$aUNRESTRICTED