Journal Article

DKFZ-2021-00442

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Aβ misfolding in blood plasma measured by immuno-infrared-sensor as an age-independent risk marker of Alzheimer's disease.

Möllers, T. (First author)DKFZ* ; Stocker, H.DKFZ* ; Perna, L.DKFZ* ; Nabers, A. ; Rujescu, D. ; Hartmann, A. M. ; Holleczek, B. ; Schöttker, B.DKFZ* ; Gerwert, K. ; Brenner, H. (Last author)DKFZ*

2021
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/dad2.12151

Abstract: Determining potential risk factors of amyloid beta (Aβ) misfolding in blood, a risk marker for clinical Alzheimer's disease (AD), could have important implications for its utility in future research and clinical settings.Participants aged 50 to 75 years attending a general health examination were recruited for a prospective community-based cohort study in Saarland, Germany, in 2000 to 2002. For these analyses, participants with available Aβ misfolding measurements and clinical AD information at 17-year follow-up were included (n = 444).Age did not show any association with Aβ misfolding in plasma; however, a strong association of both age and Aβ misfolding with the incidence of clinical AD was evident. Education and cardiovascular diseases were likewise not associated with Aβ misfolding.Structural measurement of Aβ misfolding in blood plasma is an age-independent risk marker of clinical AD among older adults, supporting that risk of clinical AD is already largely determined before older adulthood.

Keyword(s): Alzheimer's disease ; age ; amyloid beta misfolding ; cohort study ; risk factors

Note: #EA:C070#LA:C070#

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; ; ; Article Processing Charges ; DOAJ Seal ; Fees ; PubMed Central ; SCOPUS

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