TY  - JOUR
AU  - Möllers, Tobias
AU  - Stocker, Hannah
AU  - Perna, Laura
AU  - Nabers, Andreas
AU  - Rujescu, Dan
AU  - Hartmann, Annette M
AU  - Holleczek, Bernd
AU  - Schöttker, Ben
AU  - Gerwert, Klaus
AU  - Brenner, Hermann
TI  - Aβ misfolding in blood plasma measured by immuno-infrared-sensor as an age-independent risk marker of Alzheimer's disease.
JO  - Alzheimer's & dementia / Diagnosis, assessment & disease monitoring
VL  - 13
IS  - 1
SN  - 2352-8729
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2021-00442
SP  - e12151
PY  - 2021
N1  - #EA:C070#LA:C070#
AB  - Determining potential risk factors of amyloid beta (Aβ) misfolding in blood, a risk marker for clinical Alzheimer's disease (AD), could have important implications for its utility in future research and clinical settings.Participants aged 50 to 75 years attending a general health examination were recruited for a prospective community-based cohort study in Saarland, Germany, in 2000 to 2002. For these analyses, participants with available Aβ misfolding measurements and clinical AD information at 17-year follow-up were included (n = 444).Age did not show any association with Aβ misfolding in plasma; however, a strong association of both age and Aβ misfolding with the incidence of clinical AD was evident. Education and cardiovascular diseases were likewise not associated with Aβ misfolding.Structural measurement of Aβ misfolding in blood plasma is an age-independent risk marker of clinical AD among older adults, supporting that risk of clinical AD is already largely determined before older adulthood.
KW  - Alzheimer's disease (Other)
KW  - age (Other)
KW  - amyloid beta misfolding (Other)
KW  - cohort study (Other)
KW  - risk factors (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33614887
C2  - pmc:PMC7875190
DO  - DOI:10.1002/dad2.12151
UR  - https://inrepo02.dkfz.de/record/167577
ER  -