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@ARTICLE{Mllers:167577,
      author       = {T. Möllers$^*$ and H. Stocker$^*$ and L. Perna$^*$ and A.
                      Nabers and D. Rujescu and A. M. Hartmann and B. Holleczek
                      and B. Schöttker$^*$ and K. Gerwert and H. Brenner$^*$},
      title        = {{A}β misfolding in blood plasma measured by
                      immuno-infrared-sensor as an age-independent risk marker of
                      {A}lzheimer's disease.},
      journal      = {Alzheimer's $\&$ dementia / Diagnosis, assessment $\&$
                      disease monitoring},
      volume       = {13},
      number       = {1},
      issn         = {2352-8729},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2021-00442},
      pages        = {e12151},
      year         = {2021},
      note         = {#EA:C070#LA:C070#},
      abstract     = {Determining potential risk factors of amyloid beta (Aβ)
                      misfolding in blood, a risk marker for clinical Alzheimer's
                      disease (AD), could have important implications for its
                      utility in future research and clinical
                      settings.Participants aged 50 to 75 years attending a
                      general health examination were recruited for a prospective
                      community-based cohort study in Saarland, Germany, in 2000
                      to 2002. For these analyses, participants with available Aβ
                      misfolding measurements and clinical AD information at
                      17-year follow-up were included (n = 444).Age did not show
                      any association with Aβ misfolding in plasma; however, a
                      strong association of both age and Aβ misfolding with the
                      incidence of clinical AD was evident. Education and
                      cardiovascular diseases were likewise not associated with
                      Aβ misfolding.Structural measurement of Aβ misfolding in
                      blood plasma is an age-independent risk marker of clinical
                      AD among older adults, supporting that risk of clinical AD
                      is already largely determined before older adulthood.},
      keywords     = {Alzheimer's disease (Other) / age (Other) / amyloid beta
                      misfolding (Other) / cohort study (Other) / risk factors
                      (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33614887},
      pmc          = {pmc:PMC7875190},
      doi          = {10.1002/dad2.12151},
      url          = {https://inrepo02.dkfz.de/record/167577},
}