%0 Journal Article
%A Huynh-Le, Minh-Phuong
%A Fan, Chun Chieh
%A Karunamuni, Roshan
%A Thompson, Wesley K
%A Martinez, Maria Elena
%A Eeles, Rosalind A
%A Kote-Jarai, Zsofia
%A Muir, Kenneth
%A Schleutker, Johanna
%A Pashayan, Nora
%A Batra, Jyotsna
%A Grönberg, Henrik
%A Neal, David E
%A Donovan, Jenny L
%A Hamdy, Freddie C
%A Martin, Richard M
%A Nielsen, Sune F
%A Nordestgaard, Børge G
%A Wiklund, Fredrik
%A Tangen, Catherine M
%A Giles, Graham G
%A Wolk, Alicja
%A Albanes, Demetrius
%A Travis, Ruth C
%A Blot, William J
%A Zheng, Wei
%A Sanderson, Maureen
%A Stanford, Janet L
%A Mucci, Lorelei A
%A West, Catharine M L
%A Kibel, Adam S
%A Cussenot, Olivier
%A Berndt, Sonja I
%A Koutros, Stella
%A Sørensen, Karina Dalsgaard
%A Cybulski, Cezary
%A Grindedal, Eli Marie
%A Menegaux, Florence
%A Khaw, Kay-Tee
%A Park, Jong Y
%A Ingles, Sue A
%A Maier, Christiane
%A Hamilton, Robert J
%A Thibodeau, Stephen N
%A Rosenstein, Barry S
%A Lu, Yong-Jie
%A Watya, Stephen
%A Vega, Ana
%A Kogevinas, Manolis
%A Penney, Kathryn L
%A Huff, Chad
%A Teixeira, Manuel R
%A Multigner, Luc
%A Leach, Robin J
%A Cannon-Albright, Lisa
%A Brenner, Hermann
%A John, Esther M
%A Kaneva, Radka
%A Logothetis, Christopher J
%A Neuhausen, Susan L
%A De Ruyck, Kim
%A Pandha, Hardev
%A Razack, Azad
%A Newcomb, Lisa F
%A Fowke, Jay H
%A Gamulin, Marija
%A Usmani, Nawaid
%A Claessens, Frank
%A Gago-Dominguez, Manuela
%A Townsend, Paul A
%A Bush, William S
%A Roobol, Monique J
%A Parent, Marie-Élise
%A Hu, Jennifer J
%A Mills, Ian G
%A Andreassen, Ole A
%A Dale, Anders M
%A Seibert, Tyler M
%A Committee, IMPACT Study Steering
%T Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.
%J Nature Communications
%V 12
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M DKFZ-2021-00488
%P 1236
%D 2021
%X Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10-180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33623038
%R 10.1038/s41467-021-21287-0
%U https://inrepo02.dkfz.de/record/167654