Journal Article

DKFZ-2021-00488

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.

Huynh-Le, M.-P. ; Fan, C. C. ; Karunamuni, R. ; Thompson, W. K. ; Martinez, M. E. ; Eeles, R. A. ; Kote-Jarai, Z. ; Muir, K. ; Schleutker, J. ; Pashayan, N. ; Batra, J. ; Grönberg, H. ; Neal, D. E. ; Donovan, J. L. ; Hamdy, F. C. ; Martin, R. M. ; Nielsen, S. F. ; Nordestgaard, B. G. ; Wiklund, F. ; Tangen, C. M. ; Giles, G. G. ; Wolk, A. ; Albanes, D. ; Travis, R. C. ; Blot, W. J. ; Zheng, W. ; Sanderson, M. ; Stanford, J. L. ; Mucci, L. A. ; West, C. M. L. ; Kibel, A. S. ; Cussenot, O. ; Berndt, S. I. ; Koutros, S. ; Sørensen, K. D. ; Cybulski, C. ; Grindedal, E. M. ; Menegaux, F. ; Khaw, K.-T. ; Park, J. Y. ; Ingles, S. A. ; Maier, C. ; Hamilton, R. J. ; Thibodeau, S. N. ; Rosenstein, B. S. ; Lu, Y.-J. ; Watya, S. ; Vega, A. ; Kogevinas, M. ; Penney, K. L. ; Huff, C. ; Teixeira, M. R. ; Multigner, L. ; Leach, R. J. ; Cannon-Albright, L. ; Brenner, H.DKFZ* ; John, E. M. ; Kaneva, R. ; Logothetis, C. J. ; Neuhausen, S. L. ; De Ruyck, K. ; Pandha, H. ; Razack, A. ; Newcomb, L. F. ; Fowke, J. H. ; Gamulin, M. ; Usmani, N. ; Claessens, F. ; Gago-Dominguez, M. ; Townsend, P. A. ; Bush, W. S. ; Roobol, M. J. ; Parent, M.-É. ; Hu, J. J. ; Mills, I. G. ; Andreassen, O. A. ; Dale, A. M. ; Seibert, T. M. ; UKGPCS collaborators (Collaboration Author) ; APCB (Collaboration Author) ; Investigators, N. P. (Collaboration Author) ; Committee, I. S. S. ; Collaborators (Collaboration Author) ; Investigators, C. P. (Collaboration Author) ; Committee, P. S. S. (Collaboration Author) ; Consortium, P. (Collaboration Author)

2021
Nature Publishing Group UK [London]

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Please use a persistent id in citations: doi:10.1038/s41467-021-21287-0

Abstract: Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10-180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)
2. Präventive Onkologie (C120)
3. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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