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000167654 1001_ $$00000-0002-5025-4709$$aHuynh-Le, Minh-Phuong$$b0
000167654 245__ $$aPolygenic hazard score is associated with prostate cancer in multi-ethnic populations.
000167654 260__ $$a[London]$$bNature Publishing Group UK$$c2021
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000167654 520__ $$aGenetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10-180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.
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000167654 7001_ $$00000-0001-9437-2128$$aFan, Chun Chieh$$b1
000167654 7001_ $$aKarunamuni, Roshan$$b2
000167654 7001_ $$aThompson, Wesley K$$b3
000167654 7001_ $$aMartinez, Maria Elena$$b4
000167654 7001_ $$00000-0002-3698-6241$$aEeles, Rosalind A$$b5
000167654 7001_ $$aKote-Jarai, Zsofia$$b6
000167654 7001_ $$00000-0001-6429-988X$$aMuir, Kenneth$$b7
000167654 7001_ $$00000-0002-1863-0305$$aSchleutker, Johanna$$b8
000167654 7001_ $$00000-0003-0843-2468$$aPashayan, Nora$$b9
000167654 7001_ $$00000-0003-4646-6247$$aBatra, Jyotsna$$b10
000167654 7001_ $$00000-0002-1073-2753$$aGrönberg, Henrik$$b11
000167654 7001_ $$aNeal, David E$$b12
000167654 7001_ $$aDonovan, Jenny L$$b13
000167654 7001_ $$aHamdy, Freddie C$$b14
000167654 7001_ $$00000-0002-7992-7719$$aMartin, Richard M$$b15
000167654 7001_ $$aNielsen, Sune F$$b16
000167654 7001_ $$00000-0002-1954-7220$$aNordestgaard, Børge G$$b17
000167654 7001_ $$00000-0002-4623-0544$$aWiklund, Fredrik$$b18
000167654 7001_ $$aTangen, Catherine M$$b19
000167654 7001_ $$00000-0003-4946-9099$$aGiles, Graham G$$b20
000167654 7001_ $$00000-0001-7387-6845$$aWolk, Alicja$$b21
000167654 7001_ $$aAlbanes, Demetrius$$b22
000167654 7001_ $$00000-0002-9571-0763$$aTravis, Ruth C$$b23
000167654 7001_ $$aBlot, William J$$b24
000167654 7001_ $$00000-0003-1226-070X$$aZheng, Wei$$b25
000167654 7001_ $$aSanderson, Maureen$$b26
000167654 7001_ $$aStanford, Janet L$$b27
000167654 7001_ $$aMucci, Lorelei A$$b28
000167654 7001_ $$00000-0002-0839-3449$$aWest, Catharine M L$$b29
000167654 7001_ $$aKibel, Adam S$$b30
000167654 7001_ $$aCussenot, Olivier$$b31
000167654 7001_ $$aBerndt, Sonja I$$b32
000167654 7001_ $$aKoutros, Stella$$b33
000167654 7001_ $$00000-0002-4902-5490$$aSørensen, Karina Dalsgaard$$b34
000167654 7001_ $$aCybulski, Cezary$$b35
000167654 7001_ $$aGrindedal, Eli Marie$$b36
000167654 7001_ $$aMenegaux, Florence$$b37
000167654 7001_ $$aKhaw, Kay-Tee$$b38
000167654 7001_ $$aPark, Jong Y$$b39
000167654 7001_ $$aIngles, Sue A$$b40
000167654 7001_ $$aMaier, Christiane$$b41
000167654 7001_ $$aHamilton, Robert J$$b42
000167654 7001_ $$aThibodeau, Stephen N$$b43
000167654 7001_ $$aRosenstein, Barry S$$b44
000167654 7001_ $$aLu, Yong-Jie$$b45
000167654 7001_ $$aWatya, Stephen$$b46
000167654 7001_ $$00000-0002-7416-5137$$aVega, Ana$$b47
000167654 7001_ $$aKogevinas, Manolis$$b48
000167654 7001_ $$aPenney, Kathryn L$$b49
000167654 7001_ $$aHuff, Chad$$b50
000167654 7001_ $$00000-0002-4896-5982$$aTeixeira, Manuel R$$b51
000167654 7001_ $$00000-0003-3205-8568$$aMultigner, Luc$$b52
000167654 7001_ $$aLeach, Robin J$$b53
000167654 7001_ $$00000-0003-2602-3668$$aCannon-Albright, Lisa$$b54
000167654 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b55$$udkfz
000167654 7001_ $$aJohn, Esther M$$b56
000167654 7001_ $$aKaneva, Radka$$b57
000167654 7001_ $$aLogothetis, Christopher J$$b58
000167654 7001_ $$aNeuhausen, Susan L$$b59
000167654 7001_ $$aDe Ruyck, Kim$$b60
000167654 7001_ $$aPandha, Hardev$$b61
000167654 7001_ $$aRazack, Azad$$b62
000167654 7001_ $$aNewcomb, Lisa F$$b63
000167654 7001_ $$aFowke, Jay H$$b64
000167654 7001_ $$00000-0003-2431-7910$$aGamulin, Marija$$b65
000167654 7001_ $$aUsmani, Nawaid$$b66
000167654 7001_ $$aClaessens, Frank$$b67
000167654 7001_ $$aGago-Dominguez, Manuela$$b68
000167654 7001_ $$aTownsend, Paul A$$b69
000167654 7001_ $$00000-0002-9729-6519$$aBush, William S$$b70
000167654 7001_ $$00000-0001-6967-1708$$aRoobol, Monique J$$b71
000167654 7001_ $$aParent, Marie-Élise$$b72
000167654 7001_ $$aHu, Jennifer J$$b73
000167654 7001_ $$aMills, Ian G$$b74
000167654 7001_ $$00000-0002-4461-3568$$aAndreassen, Ole A$$b75
000167654 7001_ $$aDale, Anders M$$b76
000167654 7001_ $$00000-0002-4089-7399$$aSeibert, Tyler M$$b77
000167654 7001_ $$aUKGPCS collaborators$$b78$$eCollaboration Author
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000167654 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-021-21287-0$$gVol. 12, no. 1, p. 1236$$n1$$p1236$$tNature Communications$$v12$$x2041-1723$$y2021
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