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@ARTICLE{HuynhLe:167654,
      author       = {M.-P. Huynh-Le and C. C. Fan and R. Karunamuni and W. K.
                      Thompson and M. E. Martinez and R. A. Eeles and Z.
                      Kote-Jarai and K. Muir and J. Schleutker and N. Pashayan and
                      J. Batra and H. Grönberg and D. E. Neal and J. L. Donovan
                      and F. C. Hamdy and R. M. Martin and S. F. Nielsen and B. G.
                      Nordestgaard and F. Wiklund and C. M. Tangen and G. G. Giles
                      and A. Wolk and D. Albanes and R. C. Travis and W. J. Blot
                      and W. Zheng and M. Sanderson and J. L. Stanford and L. A.
                      Mucci and C. M. L. West and A. S. Kibel and O. Cussenot and
                      S. I. Berndt and S. Koutros and K. D. Sørensen and C.
                      Cybulski and E. M. Grindedal and F. Menegaux and K.-T. Khaw
                      and J. Y. Park and S. A. Ingles and C. Maier and R. J.
                      Hamilton and S. N. Thibodeau and B. S. Rosenstein and Y.-J.
                      Lu and S. Watya and A. Vega and M. Kogevinas and K. L.
                      Penney and C. Huff and M. R. Teixeira and L. Multigner and
                      R. J. Leach and L. Cannon-Albright and H. Brenner$^*$ and E.
                      M. John and R. Kaneva and C. J. Logothetis and S. L.
                      Neuhausen and K. De Ruyck and H. Pandha and A. Razack and L.
                      F. Newcomb and J. H. Fowke and M. Gamulin and N. Usmani and
                      F. Claessens and M. Gago-Dominguez and P. A. Townsend and W.
                      S. Bush and M. J. Roobol and M.-É. Parent and J. J. Hu and
                      I. G. Mills and O. A. Andreassen and A. M. Dale and T. M.
                      Seibert and I. S. S. Committee},
      collaboration = {UKGPCS collaborators and APCB and N. P. Investigators and
                      Collaborators and C. P. Investigators and P. S. S. Committee
                      and P. Consortium},
      title        = {{P}olygenic hazard score is associated with prostate cancer
                      in multi-ethnic populations.},
      journal      = {Nature Communications},
      volume       = {12},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2021-00488},
      pages        = {1236},
      year         = {2021},
      abstract     = {Genetic models for cancer have been evaluated using almost
                      exclusively European data, which could exacerbate health
                      disparities. A polygenic hazard score (PHS1) is associated
                      with age at prostate cancer diagnosis and improves screening
                      accuracy in Europeans. Here, we evaluate performance of PHS2
                      (PHS1, adapted for OncoArray) in a multi-ethnic dataset of
                      80,491 men (49,916 cases, 30,575 controls). PHS2 is
                      associated with age at diagnosis of any and aggressive
                      (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or
                      nodal/distant metastasis) cancer and
                      prostate-cancer-specific death. Associations with cancer are
                      significant within European (n = 71,856), Asian (n = 2,382),
                      and African (n = 6,253) genetic ancestries (p < 10-180).
                      Comparing the 80th/20th PHS2 percentiles, hazard ratios for
                      prostate cancer, aggressive cancer, and
                      prostate-cancer-specific death are 5.32, 5.88, and 5.68,
                      respectively. Within European, Asian, and African
                      ancestries, hazard ratios for prostate cancer are: 5.54,
                      4.49, and 2.54, respectively. PHS2 risk-stratifies men for
                      any, aggressive, and fatal prostate cancer in a multi-ethnic
                      dataset.},
      cin          = {C070 / C120 / HD01},
      ddc          = {500},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33623038},
      doi          = {10.1038/s41467-021-21287-0},
      url          = {https://inrepo02.dkfz.de/record/167654},
}