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000167770 1001_ $$0P:(DE-He78)2af56a83857b4d1efdbac9720a9197ad$$aErben, Vanessa$$b0$$eFirst author$$udkfz
000167770 245__ $$aIndividual and joint associations of genetic risk and healthy lifestyle score with colorectal neoplasms among participants of screening colonoscopy.
000167770 260__ $$aPhiladelphia, Pa.$$bAACR$$c2021
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000167770 520__ $$aGenetic and lifestyle factors contribute to colorectal cancer risk. We investigated their individual and joint associations with various stages of colorectal carcinogenesis. We assessed associations of a polygenic risk score (PRS) and a healthy lifestyle score (HLS) with presence of non-advanced adenomas and advanced neoplasms among 2585 participants of screening colonoscopy from Germany. The PRS and HLS individually showed only weak associations with presence of non-advanced adenomas; stronger associations were observed with advanced neoplasms (odds ratios, 95% CI, for highest vs. lowest risk tertile: PRS 2.27, 1.78-2.88; HLS 1.96, 1.53-2.51). The PRS was associated with higher odds of advanced neoplasms among carriers of any neoplasms (1.65, 1.23-2.22). Subjects in the highest risk tertile (vs. lowest tertile) of both scores had higher risks for non-advanced adenomas (1.77, 1.09-2.86), for advanced neoplasms (3.95, 2.53-6.16) and, among carriers of any neoplasms, for advanced vs. non-advanced neoplasms (2.26, 1.31-3.92). Both scores were individually associated with increased risk of non-advanced adenomas and, much more pronounced, advanced neoplasms. The similarly strong association in relative terms across all levels of genetic risk implies that a healthy lifestyle may be particularly beneficial in those at highest genetic risk, given that the same relative risk reduction in this group would imply a stronger absolute risk reduction. Genetic factors may be of particular relevance for the transition of non-advanced to advanced adenomas.
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000167770 7001_ $$0P:(DE-He78)7d7ee36ed0313bbc4c91bc3df5950107$$aCarr, Prudence R$$b1
000167770 7001_ $$0P:(DE-He78)0311ebf3415e41860b4e2c56fbae6919$$aGuo, Feng$$b2
000167770 7001_ $$0P:(DE-He78)f4e98340e600f7411886c21c7b778d36$$aWeigl, Korbinian$$b3
000167770 7001_ $$aHoffmeister, Michael$$b4
000167770 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b5$$eLast author
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