Journal Article

DKFZ-2021-00534

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Individual and joint associations of genetic risk and healthy lifestyle score with colorectal neoplasms among participants of screening colonoscopy.

Erben, V. (First author)DKFZ* ; Carr, P. R.DKFZ* ; Guo, F.DKFZ* ; Weigl, K.DKFZ* ; Hoffmeister, M. ; Brenner, H. (Last author)DKFZ*

2021
AACR Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1158/1940-6207.CAPR-20-0576

Abstract: Genetic and lifestyle factors contribute to colorectal cancer risk. We investigated their individual and joint associations with various stages of colorectal carcinogenesis. We assessed associations of a polygenic risk score (PRS) and a healthy lifestyle score (HLS) with presence of non-advanced adenomas and advanced neoplasms among 2585 participants of screening colonoscopy from Germany. The PRS and HLS individually showed only weak associations with presence of non-advanced adenomas; stronger associations were observed with advanced neoplasms (odds ratios, 95% CI, for highest vs. lowest risk tertile: PRS 2.27, 1.78-2.88; HLS 1.96, 1.53-2.51). The PRS was associated with higher odds of advanced neoplasms among carriers of any neoplasms (1.65, 1.23-2.22). Subjects in the highest risk tertile (vs. lowest tertile) of both scores had higher risks for non-advanced adenomas (1.77, 1.09-2.86), for advanced neoplasms (3.95, 2.53-6.16) and, among carriers of any neoplasms, for advanced vs. non-advanced neoplasms (2.26, 1.31-3.92). Both scores were individually associated with increased risk of non-advanced adenomas and, much more pronounced, advanced neoplasms. The similarly strong association in relative terms across all levels of genetic risk implies that a healthy lifestyle may be particularly beneficial in those at highest genetic risk, given that the same relative risk reduction in this group would imply a stronger absolute risk reduction. Genetic factors may be of particular relevance for the transition of non-advanced to advanced adenomas.

Note: #EA:C120#LA:C070# / 14(6):649-658

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Contributing Institute(s):

1. Präventive Onkologie (C120)
2. C070 Klinische Epidemiologie und Alternf. (C070)
3. DKTK HD zentral (HD01)
4. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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