AU  - Erben, Vanessa
AU  - Carr, Prudence R
AU  - Guo, Feng
AU  - Weigl, Korbinian
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Individual and joint associations of genetic risk and healthy lifestyle score with colorectal neoplasms among participants of screening colonoscopy.
JO  - Cancer Prevention Research
VL  - 14
IS  - 6
SN  - 1940-6215
CY  - Philadelphia, Pa.
M1  - DKFZ-2021-00534
SP  - 649-658
PY  - 2021
N1  - #EA:C120#LA:C070# / 14(6):649-658
AB  - Genetic and lifestyle factors contribute to colorectal cancer risk. We investigated their individual and joint associations with various stages of colorectal carcinogenesis. We assessed associations of a polygenic risk score (PRS) and a healthy lifestyle score (HLS) with presence of non-advanced adenomas and advanced neoplasms among 2585 participants of screening colonoscopy from Germany. The PRS and HLS individually showed only weak associations with presence of non-advanced adenomas; stronger associations were observed with advanced neoplasms (odds ratios, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:33653736
DO  - DOI:10.1158/1940-6207.CAPR-20-0576
UR  - https://inrepo02.dkfz.de/record/167770
ER  -