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100 1 _ |a Erben, Vanessa
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245 _ _ |a Individual and joint associations of genetic risk and healthy lifestyle score with colorectal neoplasms among participants of screening colonoscopy.
260 _ _ |a Philadelphia, Pa.
|c 2021
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500 _ _ |a #EA:C120#LA:C070# / 14(6):649-658
520 _ _ |a Genetic and lifestyle factors contribute to colorectal cancer risk. We investigated their individual and joint associations with various stages of colorectal carcinogenesis. We assessed associations of a polygenic risk score (PRS) and a healthy lifestyle score (HLS) with presence of non-advanced adenomas and advanced neoplasms among 2585 participants of screening colonoscopy from Germany. The PRS and HLS individually showed only weak associations with presence of non-advanced adenomas; stronger associations were observed with advanced neoplasms (odds ratios, 95% CI, for highest vs. lowest risk tertile: PRS 2.27, 1.78-2.88; HLS 1.96, 1.53-2.51). The PRS was associated with higher odds of advanced neoplasms among carriers of any neoplasms (1.65, 1.23-2.22). Subjects in the highest risk tertile (vs. lowest tertile) of both scores had higher risks for non-advanced adenomas (1.77, 1.09-2.86), for advanced neoplasms (3.95, 2.53-6.16) and, among carriers of any neoplasms, for advanced vs. non-advanced neoplasms (2.26, 1.31-3.92). Both scores were individually associated with increased risk of non-advanced adenomas and, much more pronounced, advanced neoplasms. The similarly strong association in relative terms across all levels of genetic risk implies that a healthy lifestyle may be particularly beneficial in those at highest genetic risk, given that the same relative risk reduction in this group would imply a stronger absolute risk reduction. Genetic factors may be of particular relevance for the transition of non-advanced to advanced adenomas.
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700 1 _ |a Carr, Prudence R
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700 1 _ |a Guo, Feng
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700 1 _ |a Weigl, Korbinian
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700 1 _ |a Hoffmeister, Michael
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700 1 _ |a Brenner, Hermann
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773 _ _ |a 10.1158/1940-6207.CAPR-20-0576
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