%0 Journal Article
%A Ose, Jennifer
%A Gigic, Biljana
%A Brezina, Stefanie
%A Lin, Tengda
%A Baierl, Andreas
%A Geijsen, Anne J M R
%A van Roekel, Eline
%A Robinot, Nivonirina
%A Gicquiau, Audrey
%A Achaintre, David
%A Keski-Rahkonen, Pekka
%A Duijnhoven, Fränzel J B van
%A Gumpenberger, Tanja
%A Holowatyj, Andreana N
%A Kok, Dieuwertje E
%A Koole, Annaleen
%A Schrotz-King, Petra
%A Ulrich, Alexis B
%A Schneider, Martin
%A Ulvik, Arve
%A Ueland, Per-Magne
%A Weijenberg, Matty P
%A Habermann, Nina
%A Scalbert, Augustin
%A Gsur, Andrea
%A M Ulrich, Cornelia
%T Targeted Plasma Metabolic Profiles and Risk of Recurrence in Stage II and III Colorectal Cancer Patients: Results from an International Cohort Consortium.
%J Metabolites
%V 11
%N 3
%@ 2218-1989
%C Basel
%I MDPI
%M DKFZ-2021-00582
%P 129
%D 2021
%X The identification of patients at high-risk for colorectal cancer (CRC) recurrence remains an unmet clinical need. The aim of this study was to investigate associations of metabolites with risk of recurrence in stage II/III CRC patients. A targeted metabolomics assay (128 metabolites measured) was performed on pre-surgery collected EDTA plasma samples from n = 440 newly diagnosed stage II/III CRC patients. Patients have been recruited from four prospective cohort studies as part of an international consortium: Metabolomic profiles throughout the continuum of CRC (MetaboCCC). Cox proportional hazard models were computed to investigate associations of metabolites with recurrence, adjusted for age, sex, tumor stage, tumor site, body mass index, and cohort; false discovery rate (FDR) was used to account for multiple testing. Sixty-nine patients (15
%K colorectal cancer (Other)
%K recurrence (Other)
%K targeted metabolomics (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33668370
%R 10.3390/metabo11030129
%U https://inrepo02.dkfz.de/record/167838