Journal Article

DKFZ-2021-00582

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Targeted Plasma Metabolic Profiles and Risk of Recurrence in Stage II and III Colorectal Cancer Patients: Results from an International Cohort Consortium.

Ose, J. ; Gigic, B. ; Brezina, S. ; Lin, T. ; Baierl, A. ; Geijsen, A. J. M. R. ; van Roekel, E. ; Robinot, N. ; Gicquiau, A. ; Achaintre, D. ; Keski-Rahkonen, P. ; Duijnhoven, F. J. B. v. ; Gumpenberger, T. ; Holowatyj, A. N. ; Kok, D. E. ; Koole, A. ; Schrotz-King, P.DKFZ* ; Ulrich, A. B. ; Schneider, M. ; Ulvik, A. ; Ueland, P.-M. ; Weijenberg, M. P. ; Habermann, N. ; Scalbert, A. ; Gsur, A. ; M Ulrich, C.

2021
MDPI Basel

This record in other databases:  

Please use a persistent id in citations: doi:10.3390/metabo11030129

Abstract: The identification of patients at high-risk for colorectal cancer (CRC) recurrence remains an unmet clinical need. The aim of this study was to investigate associations of metabolites with risk of recurrence in stage II/III CRC patients. A targeted metabolomics assay (128 metabolites measured) was performed on pre-surgery collected EDTA plasma samples from n = 440 newly diagnosed stage II/III CRC patients. Patients have been recruited from four prospective cohort studies as part of an international consortium: Metabolomic profiles throughout the continuum of CRC (MetaboCCC). Cox proportional hazard models were computed to investigate associations of metabolites with recurrence, adjusted for age, sex, tumor stage, tumor site, body mass index, and cohort; false discovery rate (FDR) was used to account for multiple testing. Sixty-nine patients (15%) had a recurrence after a median follow-up time of 20 months. We identified 13 metabolites that were nominally associated with a reduced risk of recurrence. None of the associations were statistically significant after controlling for multiple testing. Pathway topology analyses did not reveal statistically significant associations between recurrence and alterations in metabolic pathways (e.g., sphingolipid metabolism p = 0.04; pFDR = 1.00). To conclude, we did not observe statistically significant associations between metabolites and CRC recurrence using a well-established metabolomics assay. The observed results require follow-up in larger studies.

Keyword(s): colorectal cancer ; recurrence ; targeted metabolomics

---

Contributing Institute(s):

1. Präventive Onkologie (C120)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

---

Database coverage:
; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---