TY  - JOUR
AU  - Ose, Jennifer
AU  - Gigic, Biljana
AU  - Brezina, Stefanie
AU  - Lin, Tengda
AU  - Baierl, Andreas
AU  - Geijsen, Anne J M R
AU  - van Roekel, Eline
AU  - Robinot, Nivonirina
AU  - Gicquiau, Audrey
AU  - Achaintre, David
AU  - Keski-Rahkonen, Pekka
AU  - Duijnhoven, Fränzel J B van
AU  - Gumpenberger, Tanja
AU  - Holowatyj, Andreana N
AU  - Kok, Dieuwertje E
AU  - Koole, Annaleen
AU  - Schrotz-King, Petra
AU  - Ulrich, Alexis B
AU  - Schneider, Martin
AU  - Ulvik, Arve
AU  - Ueland, Per-Magne
AU  - Weijenberg, Matty P
AU  - Habermann, Nina
AU  - Scalbert, Augustin
AU  - Gsur, Andrea
AU  - M Ulrich, Cornelia
TI  - Targeted Plasma Metabolic Profiles and Risk of Recurrence in Stage II and III Colorectal Cancer Patients: Results from an International Cohort Consortium.
JO  - Metabolites
VL  - 11
IS  - 3
SN  - 2218-1989
CY  - Basel
PB  - MDPI
M1  - DKFZ-2021-00582
SP  - 129
PY  - 2021
AB  - The identification of patients at high-risk for colorectal cancer (CRC) recurrence remains an unmet clinical need. The aim of this study was to investigate associations of metabolites with risk of recurrence in stage II/III CRC patients. A targeted metabolomics assay (128 metabolites measured) was performed on pre-surgery collected EDTA plasma samples from n = 440 newly diagnosed stage II/III CRC patients. Patients have been recruited from four prospective cohort studies as part of an international consortium: Metabolomic profiles throughout the continuum of CRC (MetaboCCC). Cox proportional hazard models were computed to investigate associations of metabolites with recurrence, adjusted for age, sex, tumor stage, tumor site, body mass index, and cohort; false discovery rate (FDR) was used to account for multiple testing. Sixty-nine patients (15
KW  - colorectal cancer (Other)
KW  - recurrence (Other)
KW  - targeted metabolomics (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33668370
DO  - DOI:10.3390/metabo11030129
UR  - https://inrepo02.dkfz.de/record/167838
ER  -