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@ARTICLE{Voronina:168142,
      author       = {N. Voronina$^*$ and C. Aichmüller$^*$ and T. Kolb$^*$ and
                      A. Korshunov$^*$ and M. Ryzhova and J. Barnholtz-Sloan and
                      G. Cioffi and M. Sill$^*$ and A. von Deimling$^*$ and S. M.
                      Pfister$^*$ and J. Gronych$^*$ and D. T. W. Jones$^*$ and J.
                      Frisén and M. Zapatka$^*$ and A. Ernst$^*$},
      title        = {{T}he age of adult pilocytic astrocytoma cells.},
      journal      = {Oncogene},
      volume       = {40},
      number       = {16},
      issn         = {1476-5594},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2021-00707},
      pages        = {2830-2841},
      year         = {2021},
      note         = {#EA:B420#LA:B420# /40(16):2830-2841},
      abstract     = {Adult pilocytic astrocytomas (PAs) have been regarded as
                      indistinguishable from pediatric PAs in terms of genome-wide
                      expression and methylation patterns. It has been unclear
                      whether adult PAs arise early in life and remain
                      asymptomatic until adulthood, or whether they develop during
                      adulthood. We sought to determine the age and origin of
                      adult human PAs using two types of 'marks' in the genomic
                      DNA. First, we analyzed the DNA methylation patterns of
                      adult and pediatric PAs to distinguish between PAs of
                      different anatomic locations (n = 257 PA and control brain
                      tissues). Second, we measured the concentration of nuclear
                      bomb test-derived 14C in genomic DNA (n = 14 cases), which
                      indicates the time point of the formation of human cell
                      populations. Our data suggest that adult and pediatric PAs
                      developing in the infratentorial brain are closely related
                      and potentially develop from precursor cells early in life,
                      whereas supratentorial PAs might show age and
                      location-specific differences.},
      cin          = {B420 / B060 / HD01 / B300 / B062 / B360},
      ddc          = {610},
      cid          = {I:(DE-He78)B420-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)B300-20160331 /
                      I:(DE-He78)B062-20160331 / I:(DE-He78)B360-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33731860},
      doi          = {10.1038/s41388-021-01738-0},
      url          = {https://inrepo02.dkfz.de/record/168142},
}