Journal Article

DKFZ-2021-00707

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The age of adult pilocytic astrocytoma cells.

Voronina, N. (First author)DKFZ* ; Aichmüller, C. (First author)DKFZ* ; Kolb, T. (First author)DKFZ* ; Korshunov, A.DKFZ* ; Ryzhova, M. ; Barnholtz-Sloan, J. ; Cioffi, G. ; Sill, M.DKFZ* ; von Deimling, A.DKFZ* ; Pfister, S. M.DKFZ* ; Gronych, J.DKFZ* ; Jones, D. T. W.DKFZ* ; Frisén, J. ; Zapatka, M.DKFZ* ; Ernst, A. (Last author)DKFZ*

2021
Springer Nature London

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Please use a persistent id in citations: doi:10.1038/s41388-021-01738-0

Abstract: Adult pilocytic astrocytomas (PAs) have been regarded as indistinguishable from pediatric PAs in terms of genome-wide expression and methylation patterns. It has been unclear whether adult PAs arise early in life and remain asymptomatic until adulthood, or whether they develop during adulthood. We sought to determine the age and origin of adult human PAs using two types of 'marks' in the genomic DNA. First, we analyzed the DNA methylation patterns of adult and pediatric PAs to distinguish between PAs of different anatomic locations (n = 257 PA and control brain tissues). Second, we measured the concentration of nuclear bomb test-derived 14C in genomic DNA (n = 14 cases), which indicates the time point of the formation of human cell populations. Our data suggest that adult and pediatric PAs developing in the infratentorial brain are closely related and potentially develop from precursor cells early in life, whereas supratentorial PAs might show age and location-specific differences.

Note: #EA:B420#LA:B420# /40(16):2830-2841

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Contributing Institute(s):

1. Genominstabilität in Tumoren (B420)
2. B060 Molekulare Genetik (B060)
3. DKTK HD zentral (HD01)
4. KKE Neuropathologie (B300)
5. B062 Pädiatrische Neuroonkologie (B062)
6. Pediatric Glioma (B360)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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