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@ARTICLE{Heath:168383,
      author       = {A. K. Heath and J. L. Clasen and N. P. Jayanth and M. Jenab
                      and A. Tjonneland and K. E. N. Petersen and K. Overvad and
                      B. Srour$^*$ and V. Katzke$^*$ and M. M. Bergmann and M. B.
                      Schulze and G. Masala and V. Krogh and R. Tumino and A.
                      Catalano and F. Pasanisi and M. Brustad and K. S. Olsen and
                      G. Skeie and L. Lujan-Barroso and M. Rodríguez-Barranco and
                      P. Amiano and C. Santiuste and A. Barricarte Gurrea and H.
                      Axelson and S. Ramne and B. Ljungberg and E. L. Watts and I.
                      Huybrechts and E. Weiderpass and E. Riboli and D. C. Muller},
      title        = {{S}oft drink and juice consumption and renal cell carcinoma
                      incidence and mortality in the {E}uropean {P}rospective
                      {I}nvestigation into {C}ancer and {N}utrition.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {30},
      number       = {6},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2021-00870},
      pages        = {1270-1274},
      year         = {2021},
      note         = {2021 Jun;30(6):1270-1274},
      abstract     = {Renal cell carcinoma (RCC) accounts for more than $80\%$ of
                      kidney cancers in adults and obesity is a known risk factor.
                      Regular consumption of sweetened beverages has been linked
                      to obesity and several chronic diseases including some types
                      of cancer. It is uncertain whether soft drink and juice
                      consumption is associated with risk of RCC. We investigated
                      the associations of soft drink and juice consumption with
                      RCC incidence and mortality in the European Prospective
                      Investigation into Cancer and Nutrition (EPIC).389,220 EPIC
                      participants with median age 52 years at recruitment
                      (1991-2000) were included. Cox regression yielded adjusted
                      hazard ratios (HRs) and $95\%$ confidence intervals (CIs)
                      for RCC incidence and mortality in relation to intakes of
                      juices and total, sugar-sweetened, and
                      artificially-sweetened soft drinks.888 incident RCCs and 356
                      RCC deaths were identified. In models including adjustment
                      for body mass index and energy intake, there was no higher
                      risk of incident RCC associated with consumption of juices
                      (HR per 100 g/day increment=1.03, $95\%$ CI 0.97-1.09),
                      total soft drinks (HR=1.01, 0.98-1.05), sugar-sweetened soft
                      drinks (HR=0.99, 0.94-1.05), or artificially-sweetened soft
                      drinks (HR=1.02, 0.96-1.08). In these fully-adjusted models,
                      none of the beverages were associated with RCC mortality
                      (HR, $95\%$ CI per 100 g/day increment 1.06, 0.97-1.16;
                      1.03, 0.98-1.09; 0.97, 0.89-1.07; and 1.06, 0.99-1.14,
                      respectively).Consumption of juices or soft drinks was not
                      associated with RCC incidence or mortality after adjusting
                      for obesity.Soft drink and juice intakes are unlikely to
                      play an independent role in RCC development or mortality.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33849969},
      doi          = {10.1158/1055-9965.EPI-20-1726},
      url          = {https://inrepo02.dkfz.de/record/168383},
}