Journal Article

DKFZ-2021-00870

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Soft drink and juice consumption and renal cell carcinoma incidence and mortality in the European Prospective Investigation into Cancer and Nutrition.

Heath, A. K. ; Clasen, J. L. ; Jayanth, N. P. ; Jenab, M. ; Tjonneland, A. ; Petersen, K. E. N. ; Overvad, K. ; Srour, B.DKFZ* ; Katzke, V.DKFZ* ; Bergmann, M. M. ; Schulze, M. B. ; Masala, G. ; Krogh, V. ; Tumino, R. ; Catalano, A. ; Pasanisi, F. ; Brustad, M. ; Olsen, K. S. ; Skeie, G. ; Lujan-Barroso, L. ; Rodríguez-Barranco, M. ; Amiano, P. ; Santiuste, C. ; Barricarte Gurrea, A. ; Axelson, H. ; Ramne, S. ; Ljungberg, B. ; Watts, E. L. ; Huybrechts, I. ; Weiderpass, E. ; Riboli, E. ; Muller, D. C.

2021
AACR Philadelphia, Pa.

This record in other databases:  

Please use a persistent id in citations: doi:10.1158/1055-9965.EPI-20-1726

Abstract: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of RCC. We investigated the associations of soft drink and juice consumption with RCC incidence and mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).389,220 EPIC participants with median age 52 years at recruitment (1991-2000) were included. Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for RCC incidence and mortality in relation to intakes of juices and total, sugar-sweetened, and artificially-sweetened soft drinks.888 incident RCCs and 356 RCC deaths were identified. In models including adjustment for body mass index and energy intake, there was no higher risk of incident RCC associated with consumption of juices (HR per 100 g/day increment=1.03, 95% CI 0.97-1.09), total soft drinks (HR=1.01, 0.98-1.05), sugar-sweetened soft drinks (HR=0.99, 0.94-1.05), or artificially-sweetened soft drinks (HR=1.02, 0.96-1.08). In these fully-adjusted models, none of the beverages were associated with RCC mortality (HR, 95% CI per 100 g/day increment 1.06, 0.97-1.16; 1.03, 0.98-1.09; 0.97, 0.89-1.07; and 1.06, 0.99-1.14, respectively).Consumption of juices or soft drinks was not associated with RCC incidence or mortality after adjusting for obesity.Soft drink and juice intakes are unlikely to play an independent role in RCC development or mortality.

Note: 2021 Jun;30(6):1270-1274

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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