%0 Journal Article
%A Rühle, Alexander
%A Grosu, Anca-Ligia
%A Nicolay, Nils
%T The Particle Radiobiology of Multipotent Mesenchymal Stromal Cells: A Key to Mitigating Radiation-Induced Tissue Toxicities in Cancer Treatment and Beyond?
%J Frontiers in oncology
%V 11
%@ 2234-943X
%C Lausanne
%I Frontiers Media
%M DKFZ-2021-00972
%P 616831
%D 2021
%Z #EA:E055#LA:E055#
%X Mesenchymal stromal cells (MSCs) comprise a heterogeneous population of multipotent stromal cells that have gained attention for the treatment of irradiation-induced normal tissue toxicities due to their regenerative abilities. As the vast majority of studies focused on the effects of MSCs for photon irradiation-induced toxicities, little is known about the regenerative abilities of MSCs for particle irradiation-induced tissue damage or the effects of particle irradiation on the stem cell characteristics of MSCs themselves. MSC-based therapies may help treat particle irradiation-related tissue lesions in the context of cancer radiotherapy. As the number of clinical proton therapy centers is increasing, there is a need to decidedly investigate MSC-based treatments for particle irradiation-induced sequelae. Furthermore, therapies with MSCs or MSC-derived exosomes may also become a useful tool for manned space exploration or after radiation accidents and nuclear terrorism. However, such treatments require an in-depth knowledge about the effects of particle radiation on MSCs and the effects of MSCs on particle radiation-injured tissues. Here, the existing body of evidence regarding the particle radiobiology of MSCs as well as regarding MSC-based treatments for some typical particle irradiation-induced toxicities is presented and critically discussed.
%K mesenchymal stem cells (Other)
%K mesenchymal stromal cells (Other)
%K normal tissue toxicities (Other)
%K particle irradiation (Other)
%K radiation accidents (Other)
%K radiotherapy (Other)
%K space irradiation (Other)
%K stem cell therapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33912447
%2 pmc:PMC8071947
%R 10.3389/fonc.2021.616831
%U https://inrepo02.dkfz.de/record/168555