Journal Article (Review Article)

DKFZ-2021-00972

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Particle Radiobiology of Multipotent Mesenchymal Stromal Cells: A Key to Mitigating Radiation-Induced Tissue Toxicities in Cancer Treatment and Beyond?

Rühle, A. (First author)DKFZ* ; Grosu, A.-L.DKFZ* ; Nicolay, N. (Last author)DKFZ*

2021
Frontiers Media Lausanne

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Please use a persistent id in citations: doi:10.3389/fonc.2021.616831

Abstract: Mesenchymal stromal cells (MSCs) comprise a heterogeneous population of multipotent stromal cells that have gained attention for the treatment of irradiation-induced normal tissue toxicities due to their regenerative abilities. As the vast majority of studies focused on the effects of MSCs for photon irradiation-induced toxicities, little is known about the regenerative abilities of MSCs for particle irradiation-induced tissue damage or the effects of particle irradiation on the stem cell characteristics of MSCs themselves. MSC-based therapies may help treat particle irradiation-related tissue lesions in the context of cancer radiotherapy. As the number of clinical proton therapy centers is increasing, there is a need to decidedly investigate MSC-based treatments for particle irradiation-induced sequelae. Furthermore, therapies with MSCs or MSC-derived exosomes may also become a useful tool for manned space exploration or after radiation accidents and nuclear terrorism. However, such treatments require an in-depth knowledge about the effects of particle radiation on MSCs and the effects of MSCs on particle radiation-injured tissues. Here, the existing body of evidence regarding the particle radiobiology of MSCs as well as regarding MSC-based treatments for some typical particle irradiation-induced toxicities is presented and critically discussed.

Keyword(s): mesenchymal stem cells ; mesenchymal stromal cells ; normal tissue toxicities ; particle irradiation ; radiation accidents ; radiotherapy ; space irradiation ; stem cell therapy

Note: #EA:E055#LA:E055#

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Contributing Institute(s):

1. E055 KKE Molekulare Radioonkologie (E055)
2. DKTK FR zentral (FR01)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2021

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