TY  - JOUR
AU  - Rühle, Alexander
AU  - Grosu, Anca-Ligia
AU  - Nicolay, Nils
TI  - The Particle Radiobiology of Multipotent Mesenchymal Stromal Cells: A Key to Mitigating Radiation-Induced Tissue Toxicities in Cancer Treatment and Beyond?
JO  - Frontiers in oncology
VL  - 11
SN  - 2234-943X
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2021-00972
SP  - 616831
PY  - 2021
N1  - #EA:E055#LA:E055#
AB  - Mesenchymal stromal cells (MSCs) comprise a heterogeneous population of multipotent stromal cells that have gained attention for the treatment of irradiation-induced normal tissue toxicities due to their regenerative abilities. As the vast majority of studies focused on the effects of MSCs for photon irradiation-induced toxicities, little is known about the regenerative abilities of MSCs for particle irradiation-induced tissue damage or the effects of particle irradiation on the stem cell characteristics of MSCs themselves. MSC-based therapies may help treat particle irradiation-related tissue lesions in the context of cancer radiotherapy. As the number of clinical proton therapy centers is increasing, there is a need to decidedly investigate MSC-based treatments for particle irradiation-induced sequelae. Furthermore, therapies with MSCs or MSC-derived exosomes may also become a useful tool for manned space exploration or after radiation accidents and nuclear terrorism. However, such treatments require an in-depth knowledge about the effects of particle radiation on MSCs and the effects of MSCs on particle radiation-injured tissues. Here, the existing body of evidence regarding the particle radiobiology of MSCs as well as regarding MSC-based treatments for some typical particle irradiation-induced toxicities is presented and critically discussed.
KW  - mesenchymal stem cells (Other)
KW  - mesenchymal stromal cells (Other)
KW  - normal tissue toxicities (Other)
KW  - particle irradiation (Other)
KW  - radiation accidents (Other)
KW  - radiotherapy (Other)
KW  - space irradiation (Other)
KW  - stem cell therapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33912447
C2  - pmc:PMC8071947
DO  - DOI:10.3389/fonc.2021.616831
UR  - https://inrepo02.dkfz.de/record/168555
ER  -