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@ARTICLE{Rhle:168555,
      author       = {A. Rühle$^*$ and A.-L. Grosu$^*$ and N. Nicolay$^*$},
      title        = {{T}he {P}article {R}adiobiology of {M}ultipotent
                      {M}esenchymal {S}tromal {C}ells: {A} {K}ey to {M}itigating
                      {R}adiation-{I}nduced {T}issue {T}oxicities in {C}ancer
                      {T}reatment and {B}eyond?},
      journal      = {Frontiers in oncology},
      volume       = {11},
      issn         = {2234-943X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2021-00972},
      pages        = {616831},
      year         = {2021},
      note         = {#EA:E055#LA:E055#},
      abstract     = {Mesenchymal stromal cells (MSCs) comprise a heterogeneous
                      population of multipotent stromal cells that have gained
                      attention for the treatment of irradiation-induced normal
                      tissue toxicities due to their regenerative abilities. As
                      the vast majority of studies focused on the effects of MSCs
                      for photon irradiation-induced toxicities, little is known
                      about the regenerative abilities of MSCs for particle
                      irradiation-induced tissue damage or the effects of particle
                      irradiation on the stem cell characteristics of MSCs
                      themselves. MSC-based therapies may help treat particle
                      irradiation-related tissue lesions in the context of cancer
                      radiotherapy. As the number of clinical proton therapy
                      centers is increasing, there is a need to decidedly
                      investigate MSC-based treatments for particle
                      irradiation-induced sequelae. Furthermore, therapies with
                      MSCs or MSC-derived exosomes may also become a useful tool
                      for manned space exploration or after radiation accidents
                      and nuclear terrorism. However, such treatments require an
                      in-depth knowledge about the effects of particle radiation
                      on MSCs and the effects of MSCs on particle
                      radiation-injured tissues. Here, the existing body of
                      evidence regarding the particle radiobiology of MSCs as well
                      as regarding MSC-based treatments for some typical particle
                      irradiation-induced toxicities is presented and critically
                      discussed.},
      subtyp        = {Review Article},
      keywords     = {mesenchymal stem cells (Other) / mesenchymal stromal cells
                      (Other) / normal tissue toxicities (Other) / particle
                      irradiation (Other) / radiation accidents (Other) /
                      radiotherapy (Other) / space irradiation (Other) / stem cell
                      therapy (Other)},
      cin          = {E055 / FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)E055-20160331 / I:(DE-He78)FR01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33912447},
      pmc          = {pmc:PMC8071947},
      doi          = {10.3389/fonc.2021.616831},
      url          = {https://inrepo02.dkfz.de/record/168555},
}