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000168707 041__ $$aEnglish
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000168707 1001_ $$aEisele, Yannick$$b0
000168707 245__ $$aFusobacterium nucleatum and Clinicopathologic Features of Colorectal Cancer: Results From the ColoCare Study.
000168707 260__ $$aDallas, Tex.$$bCancer Information Group$$c2021
000168707 264_1 $$2Crossref$$3print$$bElsevier BV$$c2021-09-01
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000168707 520__ $$aFusobacterium nucleatum (Fn), a bacterium associated with a wide spectrum of infections, has emerged as a key microbe in colorectal carcinogenesis. However, the underlying mechanisms and clinical relevance of Fn in colorectal cancer (CRC) remain incompletely understood.We examined associations between Fn abundance and clinicopathologic characteristics among 105 treatment-naïve CRC patients enrolled in the international, prospective ColoCare Study. Electronic medical charts, including pathological reports, were reviewed to document clinicopathologic features. Quantitative real-time polymerase chain reaction (PCR) was used to amplify/detect Fn DNA in preoperative fecal samples. Multinomial logistic regression was used to analyze associations between Fn abundance and patient sex, age, tumor stage, grade, site, microsatellite instability, body mass index (BMI), alcohol consumption, and smoking history. Cox proportional hazards models were used to investigate associations of Fn abundance with overall survival in adjusted models.Compared to patients with undetectable or low Fn abundance, patients with high Fn abundance (n = 22) were 3-fold more likely to be diagnosed with rectal versus colon cancer (odds ratio [OR] = 3.01; 95% confidence interval [CI], 1.06-8.57; P = .04) after adjustment for patient sex, age, BMI, and study site. Patients with high Fn abundance also had a 5-fold increased risk of being diagnosed with rectal cancer versus right-sided colon cancer (OR = 5.32; 95% CI, 1.23-22.98; P = .03). There was no statistically significant association between Fn abundance and overall survival.Our findings suggest that Fn abundance in fecal samples collected prior to surgery varies by tumor site among treatment-naïve CRC patients. Overall, fecal Fn abundance may have diagnostic and prognostic significance in the clinical management of CRC.
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000168707 650_7 $$2Other$$aFusobacterium
000168707 650_7 $$2Other$$agut microbiome
000168707 650_7 $$2Other$$arectal cancer
000168707 650_7 $$2Other$$astool
000168707 650_7 $$2Other$$atumor site
000168707 7001_ $$aMallea, Patrick M$$b1
000168707 7001_ $$aGigic, Biljana$$b2
000168707 7001_ $$aStephens, W Zac$$b3
000168707 7001_ $$aWarby, Christy A$$b4
000168707 7001_ $$aBuhrke, Kate$$b5
000168707 7001_ $$aLin, Tengda$$b6
000168707 7001_ $$aBoehm, Juergen$$b7
000168707 7001_ $$0P:(DE-He78)01ef71f71b01a3ec3b698653fd43fe86$$aSchrotz-King, Petra$$b8$$udkfz
000168707 7001_ $$aHardikar, Sheetal$$b9
000168707 7001_ $$aHuang, Lyen C$$b10
000168707 7001_ $$aPickron, T Bartley$$b11
000168707 7001_ $$aScaife, Courtney L$$b12
000168707 7001_ $$aViskochil, Richard$$b13
000168707 7001_ $$aKoelsch, Torsten$$b14
000168707 7001_ $$aPeoples, Anita R$$b15
000168707 7001_ $$aPletneva, Maria A$$b16
000168707 7001_ $$aBronner, Mary$$b17
000168707 7001_ $$aSchneider, Martin$$b18
000168707 7001_ $$aUlrich, Alexis B$$b19
000168707 7001_ $$aSwanson, Eric A$$b20
000168707 7001_ $$aToriola, Adetunji T$$b21
000168707 7001_ $$aShibata, David$$b22
000168707 7001_ $$aLi, Christopher I$$b23
000168707 7001_ $$aSiegel, Erin M$$b24
000168707 7001_ $$aFigueiredo, Jane$$b25
000168707 7001_ $$aJanssen, Klaus-Peter$$b26
000168707 7001_ $$aHauner, Hans$$b27
000168707 7001_ $$aRound, June$$b28
000168707 7001_ $$aUlrich, Cornelia M$$b29
000168707 7001_ $$aHolowatyj, Andreana N$$b30
000168707 7001_ $$aOse, Jennifer$$b31
000168707 77318 $$2Crossref$$3journal-article$$a10.1016/j.clcc.2021.02.007$$bElsevier BV$$d2021-09-01$$n3$$pe165-e172$$tClinical Colorectal Cancer$$v20$$x1533-0028$$y2021
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000168707 999C5 $$1Bray$$2Crossref$$9-- missing cx lookup --$$a10.3322/caac.21492$$p394 -$$tCA Cancer J Clin$$v68$$y2018
000168707 999C5 $$1Kostic$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.chom.2013.07.007$$p207 -$$tCell Host Microbe$$v14$$y2013
000168707 999C5 $$1Brennan$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41579-018-0129-6$$p156 -$$tNat Rev Microbiol$$v17$$y2019
000168707 999C5 $$1Gursoy$$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1600-0463.2008.00868.x$$p1063 -$$tAPMIS$$v116$$y2008
000168707 999C5 $$1Kostic$$2Crossref$$9-- missing cx lookup --$$a10.1101/gr.126573.111$$p292 -$$tGenome Res$$v22$$y2012
000168707 999C5 $$1Castellarin$$2Crossref$$9-- missing cx lookup --$$a10.1101/gr.126516.111$$p299 -$$tGenome Res$$v22$$y2012
000168707 999C5 $$1Komiya$$2Crossref$$9-- missing cx lookup --$$a10.1136/gutjnl-2018-316661$$p1335 -$$tGut$$v68$$y2019
000168707 999C5 $$1Gethings-Behncke$$2Crossref$$9-- missing cx lookup --$$a10.1158/1055-9965.EPI-18-1295$$p539 -$$tCancer Epidemiol Biomarkers Prev$$v29$$y2020
000168707 999C5 $$1Tunsjo$$2Crossref$$9-- missing cx lookup --$$a10.1007/s10096-019-03562-7$$p1367 -$$tEur J Clin Microbiol Infect Dis$$v38$$y2019
000168707 999C5 $$1Roy$$2Crossref$$9-- missing cx lookup --$$a10.1038/nrc.2017.13$$p271 -$$tNat Rev Cancer$$v17$$y2017
000168707 999C5 $$1Ianiro$$2Crossref$$9-- missing cx lookup --$$a10.1136/gutjnl-2016-312297$$p1906 -$$tGut$$v65$$y2016
000168707 999C5 $$1Gevers$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.chom.2014.02.005$$p382 -$$tCell Host Microbe$$v15$$y2014
000168707 999C5 $$1Ulrich$$2Crossref$$9-- missing cx lookup --$$a10.1158/1055-9965.EPI-18-0773$$p591 -$$tCancer Epidemiol Biomarkers Prev$$v28$$y2019
000168707 999C5 $$1Himbert$$2Crossref$$9-- missing cx lookup --$$a10.1158/1055-9965.EPI-18-0654$$p76 -$$tCancer Epidemiol Biomarkers Prev$$v28$$y2019
000168707 999C5 $$1Bacchetti De Gregoris$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.mimet.2011.06.010$$p351 -$$tJ Microbiol Methods$$v86$$y2011
000168707 999C5 $$1Mima$$2Crossref$$9-- missing cx lookup --$$a10.1038/ctg.2016.53$$pe200 -$$tClin Transl Gastroenterol$$v7$$y2016
000168707 999C5 $$1Mima$$2Crossref$$9-- missing cx lookup --$$a10.1136/gutjnl-2015-310101$$p1973 -$$tGut$$v65$$y2016
000168707 999C5 $$1Oh$$2Crossref$$9-- missing cx lookup --$$a10.4132/jptm.2018.11.29$$p40 -$$tJ Pathol Transl Med$$v53$$y2019
000168707 999C5 $$1Ito$$2Crossref$$9-- missing cx lookup --$$a10.1002/ijc.29488$$p1258 -$$tInt J Cancer$$v137$$y2015
000168707 999C5 $$1Tahara$$2Crossref$$9-- missing cx lookup --$$a10.1158/0008-5472.CAN-13-1865$$p1311 -$$tCancer Res$$v74$$y2014
000168707 999C5 $$1Gupta$$2Crossref$$9-- missing cx lookup --$$a10.3389/fmicb.2017.01162$$p1162 -$$tFront Microbiol$$v8$$y2017
000168707 999C5 $$1McCoy$$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pone.0053653$$pe53653 -$$tPLoS One$$v8$$y2013
000168707 999C5 $$1Gao$$2Crossref$$9-- missing cx lookup --$$a10.1007/s10096-017-3026-4$$p2073 -$$tEur J Clin Microbiol Infect Dis$$v36$$y2017
000168707 999C5 $$1Serna$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.annonc.2020.06.003$$p1366 -$$tAnn Oncol$$v31$$y2020
000168707 999C5 $$1Brenner$$2Crossref$$9-- missing cx lookup --$$a10.1016/S0140-6736(13)61649-9$$p1490 -$$tLancet$$v383$$y2014
000168707 999C5 $$1Murphy$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cgh.2018.07.030$$tClin Gastroenterol Hepatol$$v17$$y2019
000168707 999C5 $$1Holowatyj$$2Crossref$$9-- missing cx lookup --$$a10.14309/ctg.0000000000000059$$pe00059 -$$tClin Transl Gastroenterol$$v10$$y2019
000168707 999C5 $$1White$$2Crossref$$9-- missing cx lookup --$$a10.1186/s12885-018-4786-7$$p906 -$$tBMC Cancer$$v18$$y2018
000168707 999C5 $$1Bogaert$$2Crossref$$oBogaert 2014$$y2014
000168707 999C5 $$1Wirbel$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41591-019-0406-6$$p679 -$$tNat Med$$v25$$y2019
000168707 999C5 $$1Guo$$2Crossref$$9-- missing cx lookup --$$a10.1373/clinchem.2018.289728$$p1327 -$$tClin Chem$$v64$$y2018
000168707 999C5 $$1Ohigashi$$2Crossref$$9-- missing cx lookup --$$a10.1007/s10620-012-2526-4$$p1717 -$$tDig Dis Sci$$v58$$y2013
000168707 999C5 $$1Chew$$2Crossref$$9-- missing cx lookup --$$a10.1186/1471-2180-12-189$$p189 -$$tBMC Microbiol$$v12$$y2012
000168707 999C5 $$1Mima$$2Crossref$$9-- missing cx lookup --$$a10.1001/jamaoncol.2015.1377$$p653 -$$tJAMA Oncol$$v1$$y2015
000168707 999C5 $$1Liu$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cgh.2018.04.030$$tClin Gastroenterol Hepatol$$v16$$y2018
000168707 999C5 $$1Mehta$$2Crossref$$9-- missing cx lookup --$$a10.1001/jamaoncol.2016.6374$$p921 -$$tJAMA Oncol$$v3$$y2017