Journal Article

DKFZ-2021-01015

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Fusobacterium nucleatum and Clinicopathologic Features of Colorectal Cancer: Results From the ColoCare Study.

Eisele, Y. ; Mallea, P. M. ; Gigic, B. ; Stephens, W. Z. ; Warby, C. A. ; Buhrke, K. ; Lin, T. ; Boehm, J. ; Schrotz-King, P.DKFZ* ; Hardikar, S. ; Huang, L. C. ; Pickron, T. B. ; Scaife, C. L. ; Viskochil, R. ; Koelsch, T. ; Peoples, A. R. ; Pletneva, M. A. ; Bronner, M. ; Schneider, M. ; Ulrich, A. B. ; Swanson, E. A. ; Toriola, A. T. ; Shibata, D. ; Li, C. I. ; Siegel, E. M. ; Figueiredo, J. ; Janssen, K.-P. ; Hauner, H. ; Round, J. ; Ulrich, C. M. ; Holowatyj, A. N. ; Ose, J.

2021
Cancer Information Group Dallas, Tex.

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Please use a persistent id in citations: doi:10.1016/j.clcc.2021.02.007

Abstract: Fusobacterium nucleatum (Fn), a bacterium associated with a wide spectrum of infections, has emerged as a key microbe in colorectal carcinogenesis. However, the underlying mechanisms and clinical relevance of Fn in colorectal cancer (CRC) remain incompletely understood.We examined associations between Fn abundance and clinicopathologic characteristics among 105 treatment-naïve CRC patients enrolled in the international, prospective ColoCare Study. Electronic medical charts, including pathological reports, were reviewed to document clinicopathologic features. Quantitative real-time polymerase chain reaction (PCR) was used to amplify/detect Fn DNA in preoperative fecal samples. Multinomial logistic regression was used to analyze associations between Fn abundance and patient sex, age, tumor stage, grade, site, microsatellite instability, body mass index (BMI), alcohol consumption, and smoking history. Cox proportional hazards models were used to investigate associations of Fn abundance with overall survival in adjusted models.Compared to patients with undetectable or low Fn abundance, patients with high Fn abundance (n = 22) were 3-fold more likely to be diagnosed with rectal versus colon cancer (odds ratio [OR] = 3.01; 95% confidence interval [CI], 1.06-8.57; P = .04) after adjustment for patient sex, age, BMI, and study site. Patients with high Fn abundance also had a 5-fold increased risk of being diagnosed with rectal cancer versus right-sided colon cancer (OR = 5.32; 95% CI, 1.23-22.98; P = .03). There was no statistically significant association between Fn abundance and overall survival.Our findings suggest that Fn abundance in fecal samples collected prior to surgery varies by tumor site among treatment-naïve CRC patients. Overall, fecal Fn abundance may have diagnostic and prognostic significance in the clinical management of CRC.

Keyword(s): Fusobacterium ; gut microbiome ; rectal cancer ; stool ; tumor site

Note: 2021 Sep;20(3):e165-e172

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Contributing Institute(s):

1. Präventive Onkologie (C120)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; Current Contents - Clinical Medicine ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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