TY  - JOUR
AU  - Eisele, Yannick
AU  - Mallea, Patrick M
AU  - Gigic, Biljana
AU  - Stephens, W Zac
AU  - Warby, Christy A
AU  - Buhrke, Kate
AU  - Lin, Tengda
AU  - Boehm, Juergen
AU  - Schrotz-King, Petra
AU  - Hardikar, Sheetal
AU  - Huang, Lyen C
AU  - Pickron, T Bartley
AU  - Scaife, Courtney L
AU  - Viskochil, Richard
AU  - Koelsch, Torsten
AU  - Peoples, Anita R
AU  - Pletneva, Maria A
AU  - Bronner, Mary
AU  - Schneider, Martin
AU  - Ulrich, Alexis B
AU  - Swanson, Eric A
AU  - Toriola, Adetunji T
AU  - Shibata, David
AU  - Li, Christopher I
AU  - Siegel, Erin M
AU  - Figueiredo, Jane
AU  - Janssen, Klaus-Peter
AU  - Hauner, Hans
AU  - Round, June
AU  - Ulrich, Cornelia M
AU  - Holowatyj, Andreana N
AU  - Ose, Jennifer
TI  - Fusobacterium nucleatum and Clinicopathologic Features of Colorectal Cancer: Results From the ColoCare Study.
JO  - Clinical colorectal cancer and other gastrointestinal malignancies
VL  - 20
IS  - 3
SN  - 1533-0028
CY  - Dallas, Tex.
PB  - Cancer Information Group
M1  - DKFZ-2021-01015
SP  - e165-e172
PY  - 2021
N1  - 2021 Sep;20(3):e165-e172
AB  - Fusobacterium nucleatum (Fn), a bacterium associated with a wide spectrum of infections, has emerged as a key microbe in colorectal carcinogenesis. However, the underlying mechanisms and clinical relevance of Fn in colorectal cancer (CRC) remain incompletely understood.We examined associations between Fn abundance and clinicopathologic characteristics among 105 treatment-naïve CRC patients enrolled in the international, prospective ColoCare Study. Electronic medical charts, including pathological reports, were reviewed to document clinicopathologic features. Quantitative real-time polymerase chain reaction (PCR) was used to amplify/detect Fn DNA in preoperative fecal samples. Multinomial logistic regression was used to analyze associations between Fn abundance and patient sex, age, tumor stage, grade, site, microsatellite instability, body mass index (BMI), alcohol consumption, and smoking history. Cox proportional hazards models were used to investigate associations of Fn abundance with overall survival in adjusted models.Compared to patients with undetectable or low Fn abundance, patients with high Fn abundance (n = 22) were 3-fold more likely to be diagnosed with rectal versus colon cancer (odds ratio [OR] = 3.01; 95
KW  - Fusobacterium (Other)
KW  - gut microbiome (Other)
KW  - rectal cancer (Other)
KW  - stool (Other)
KW  - tumor site (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33935016
DO  - DOI:10.1016/j.clcc.2021.02.007
UR  - https://inrepo02.dkfz.de/record/168707
ER  -