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@ARTICLE{Eisele:168707,
      author       = {Y. Eisele and P. M. Mallea and B. Gigic and W. Z. Stephens
                      and C. A. Warby and K. Buhrke and T. Lin and J. Boehm and P.
                      Schrotz-King$^*$ and S. Hardikar and L. C. Huang and T. B.
                      Pickron and C. L. Scaife and R. Viskochil and T. Koelsch and
                      A. R. Peoples and M. A. Pletneva and M. Bronner and M.
                      Schneider and A. B. Ulrich and E. A. Swanson and A. T.
                      Toriola and D. Shibata and C. I. Li and E. M. Siegel and J.
                      Figueiredo and K.-P. Janssen and H. Hauner and J. Round and
                      C. M. Ulrich and A. N. Holowatyj and J. Ose},
      title        = {{F}usobacterium nucleatum and {C}linicopathologic
                      {F}eatures of {C}olorectal {C}ancer: {R}esults {F}rom the
                      {C}olo{C}are {S}tudy.},
      journal      = {Clinical colorectal cancer and other gastrointestinal
                      malignancies},
      volume       = {20},
      number       = {3},
      issn         = {1533-0028},
      address      = {Dallas, Tex.},
      publisher    = {Cancer Information Group},
      reportid     = {DKFZ-2021-01015},
      pages        = {e165-e172},
      year         = {2021},
      note         = {2021 Sep;20(3):e165-e172},
      abstract     = {Fusobacterium nucleatum (Fn), a bacterium associated with a
                      wide spectrum of infections, has emerged as a key microbe in
                      colorectal carcinogenesis. However, the underlying
                      mechanisms and clinical relevance of Fn in colorectal cancer
                      (CRC) remain incompletely understood.We examined
                      associations between Fn abundance and clinicopathologic
                      characteristics among 105 treatment-naïve CRC patients
                      enrolled in the international, prospective ColoCare Study.
                      Electronic medical charts, including pathological reports,
                      were reviewed to document clinicopathologic features.
                      Quantitative real-time polymerase chain reaction (PCR) was
                      used to amplify/detect Fn DNA in preoperative fecal samples.
                      Multinomial logistic regression was used to analyze
                      associations between Fn abundance and patient sex, age,
                      tumor stage, grade, site, microsatellite instability, body
                      mass index (BMI), alcohol consumption, and smoking history.
                      Cox proportional hazards models were used to investigate
                      associations of Fn abundance with overall survival in
                      adjusted models.Compared to patients with undetectable or
                      low Fn abundance, patients with high Fn abundance (n = 22)
                      were 3-fold more likely to be diagnosed with rectal versus
                      colon cancer (odds ratio [OR] = 3.01; $95\%$ confidence
                      interval [CI], 1.06-8.57; P = .04) after adjustment for
                      patient sex, age, BMI, and study site. Patients with high Fn
                      abundance also had a 5-fold increased risk of being
                      diagnosed with rectal cancer versus right-sided colon cancer
                      (OR = 5.32; $95\%$ CI, 1.23-22.98; P = .03). There was
                      no statistically significant association between Fn
                      abundance and overall survival.Our findings suggest that Fn
                      abundance in fecal samples collected prior to surgery varies
                      by tumor site among treatment-naïve CRC patients. Overall,
                      fecal Fn abundance may have diagnostic and prognostic
                      significance in the clinical management of CRC.},
      keywords     = {Fusobacterium (Other) / gut microbiome (Other) / rectal
                      cancer (Other) / stool (Other) / tumor site (Other)},
      cin          = {C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33935016},
      doi          = {10.1016/j.clcc.2021.02.007},
      url          = {https://inrepo02.dkfz.de/record/168707},
}