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000168740 041__ $$aEnglish
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000168740 1001_ $$0P:(DE-He78)02e29e2d540ff21d777f3a03ec9f5ade$$aJansen, Jeannette$$b0$$eFirst author$$udkfz
000168740 245__ $$aDoes FLASH deplete Oxygen? Experimental Evaluation for Photons, Protons and Carbon Ions.
000168740 260__ $$aCollege Park, Md.$$bAAPM$$c2021
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000168740 500__ $$a#EA:E041#LA:E041# /  2021 Jul;48(7):3982-3990
000168740 520__ $$aTo investigate experimentally, if FLASH irradiation depletes oxygen within water for different radiation types such as photons, protons and carbon ions.This study presents measurements of the oxygen consumption in sealed, 3D printed water phantoms during irradiation with X-rays, protons and carbon ions at varying dose rates up to 340Gy/s. The oxygen measurement was performed using an optical sensor allowing for non-invasive measurements.Oxygen consumption in water only depends on dose, dose rate and linear energy transfer (LET) of the irradiation. The total amount of oxygen depleted per 10Gy was found to be 0.04% atm - 0.18% atm for 225 kV photons, 0.04% atm - 0.25% atm for 224 MeV protons and 0.09% atm - 0.17% atm for carbon ions. Consumption depends on dose rate by an inverse power law and saturates for higher dose rates because of self-interactions of radicals. Higher dose rates yield lower oxygen consumption. No total depletion of oxygen was found for clinical doses.FLASH irradiation does consume oxygen, but not enough to deplete all the oxygen present. For higher dose rates, less oxygen was consumed than at standard radiotherapy dose rates. No total depletion was found for any of the analyzed radiation types for 10Gy dose delivery using FLASH.
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000168740 7001_ $$0P:(DE-He78)483e25de20b0e09c44b46bdbdd7036c2$$aKnoll, Jan$$b1$$udkfz
000168740 7001_ $$aBeyreuther, Elke$$b2
000168740 7001_ $$aPawelke, Jörg$$b3
000168740 7001_ $$0P:(DE-He78)8cc7a5c2b253317f7b005e2e6a3b7a05$$aSkuza, Raphael$$b4$$udkfz
000168740 7001_ $$0P:(DE-He78)15d0e694db442a1762a025b802a56f75$$aHanley, Rachel$$b5$$udkfz
000168740 7001_ $$aBrons, Stephan$$b6
000168740 7001_ $$0P:(DE-He78)d06e5bb2d0828caa2be79a51825e84e1$$aPagliari, Francesca$$b7$$udkfz
000168740 7001_ $$0P:(DE-He78)102624aca75cfe987c05343d5fdcf2fe$$aSeco, Joao$$b8$$eLast author$$udkfz
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