Journal Article

DKFZ-2021-01034

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Does FLASH deplete Oxygen? Experimental Evaluation for Photons, Protons and Carbon Ions.

Jansen, J. (First author)DKFZ* ; Knoll, J.DKFZ* ; Beyreuther, E. ; Pawelke, J. ; Skuza, R.DKFZ* ; Hanley, R.DKFZ* ; Brons, S. ; Pagliari, F.DKFZ* ; Seco, J. (Last author)DKFZ*

2021
AAPM College Park, Md.

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Please use a persistent id in citations: doi:10.1002/mp.14917

Abstract: To investigate experimentally, if FLASH irradiation depletes oxygen within water for different radiation types such as photons, protons and carbon ions.This study presents measurements of the oxygen consumption in sealed, 3D printed water phantoms during irradiation with X-rays, protons and carbon ions at varying dose rates up to 340Gy/s. The oxygen measurement was performed using an optical sensor allowing for non-invasive measurements.Oxygen consumption in water only depends on dose, dose rate and linear energy transfer (LET) of the irradiation. The total amount of oxygen depleted per 10Gy was found to be 0.04% atm - 0.18% atm for 225 kV photons, 0.04% atm - 0.25% atm for 224 MeV protons and 0.09% atm - 0.17% atm for carbon ions. Consumption depends on dose rate by an inverse power law and saturates for higher dose rates because of self-interactions of radicals. Higher dose rates yield lower oxygen consumption. No total depletion of oxygen was found for clinical doses.FLASH irradiation does consume oxygen, but not enough to deplete all the oxygen present. For higher dose rates, less oxygen was consumed than at standard radiotherapy dose rates. No total depletion was found for any of the analyzed radiation types for 10Gy dose delivery using FLASH.

Note: #EA:E041#LA:E041# / 2021 Jul;48(7):3982-3990

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Contributing Institute(s):

1. E041 Medizinische Physik in der Radioonkologie (E041)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2021

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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