%0 Journal Article
%A Hua, Xinwei
%A Dai, James Y
%A Lindström, Sara
%A Harrison, Tabitha A
%A Lin, Yi
%A Alberts, Steven R
%A Alwers, Elizabeth
%A Berndt, Sonja I
%A Brenner, Hermann
%A Buchanan, Daniel D
%A Campbell, Peter T
%A Casey, Graham
%A Chang-Claude, Jenny
%A Gallinger, Steven
%A Giles, Graham G
%A Goldberg, Richard M
%A Gunter, Marc J
%A Hoffmeister, Michael
%A Jenkins, Mark A
%A Joshi, Amit D
%A Ma, Wenjie
%A Milne, Roger L
%A Murphy, Neil
%A Pai, Rish K
%A Sakoda, Lori C
%A Schoen, Robert E
%A Shi, Qian
%A Slattery, Martha L
%A Song, Mingyang
%A White, Emily
%A Le Marchand, Loic
%A Chan, Andrew T
%A Peters, Ulrike
%A Newcomb, Polly A
%T Genetically predicted circulating C-reactive protein concentration and colorectal cancer survival: A Mendelian randomization consortium study.
%J Cancer epidemiology, biomarkers & prevention
%V 30
%N 7
%@ 1538-7755
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2021-01065
%P 1349-1358
%D 2021
%Z 2021 Jul;30(7):1349-1358
%X A positive association between circulating C-reactive protein (CRP) and colorectal cancer (CRC) survival was reported in observational studies, which are susceptible to unmeasured confounding and reverse causality. We used a Mendelian randomization approach to evaluate the association between genetically-predicted CRP concentrations and CRC-specific survival.We used individual-level data for 16,918 eligible CRC cases of European ancestry from 15 studies within the International Survival Analysis of Colorectal Cancer Consortium. We calculated a genetic risk score based on 52 CRP-associated genetic variants identified from genome-wide association studies. Due to the non-collapsibility of hazard ratios from Cox proportional hazards models, we used the additive hazards model to calculate hazard differences (HD) and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33972368
%R 10.1158/1055-9965.EPI-20-1848
%U https://inrepo02.dkfz.de/record/168784