Journal Article

DKFZ-2021-01065

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genetically predicted circulating C-reactive protein concentration and colorectal cancer survival: A Mendelian randomization consortium study.

Hua, X. ; Dai, J. Y. ; Lindström, S. ; Harrison, T. A. ; Lin, Y. ; Alberts, S. R. ; Alwers, E.DKFZ* ; Berndt, S. I. ; Brenner, H.DKFZ* ; Buchanan, D. D. ; Campbell, P. T. ; Casey, G. ; Chang-Claude, J.DKFZ* ; Gallinger, S. ; Giles, G. G. ; Goldberg, R. M. ; Gunter, M. J. ; Hoffmeister, M.DKFZ* ; Jenkins, M. A. ; Joshi, A. D. ; Ma, W. ; Milne, R. L. ; Murphy, N. ; Pai, R. K. ; Sakoda, L. C. ; Schoen, R. E. ; Shi, Q. ; Slattery, M. L. ; Song, M. ; White, E. ; Le Marchand, L. ; Chan, A. T. ; Peters, U. ; Newcomb, P. A.

2021
AACR Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1158/1055-9965.EPI-20-1848

Abstract: A positive association between circulating C-reactive protein (CRP) and colorectal cancer (CRC) survival was reported in observational studies, which are susceptible to unmeasured confounding and reverse causality. We used a Mendelian randomization approach to evaluate the association between genetically-predicted CRP concentrations and CRC-specific survival.We used individual-level data for 16,918 eligible CRC cases of European ancestry from 15 studies within the International Survival Analysis of Colorectal Cancer Consortium. We calculated a genetic risk score based on 52 CRP-associated genetic variants identified from genome-wide association studies. Due to the non-collapsibility of hazard ratios from Cox proportional hazards models, we used the additive hazards model to calculate hazard differences (HD) and 95% confidence intervals (CI) for the association between genetically-predicted CRP concentrations and CRC-specific survival, overall and by stage at diagnosis and tumor location. Analyses were adjusted for age at diagnosis, sex, body mass index, genotyping platform, study, and principal components.Of the 5,395 (32%) deaths accrued over up to 10 years of follow-up, 3,808 (23%) were due to CRC. Genetically-predicted CRP concentration was not associated with CRC-specific survival (HD= -1.15, 95% CI: -2.76 to 0.47 per 100,000 person-years, P =0.16). Similarly, no associations were observed in subgroup analyses by stage at diagnosis or tumor location.Despite adequate power to detect moderate associations, our results did not support a causal effect of circulating CRP concentrations on CRC-specific survival.Future research evaluating genetically-determined levels of other circulating inflammatory biomarkers (i.e. interleukin-6) with CRC survival outcomes is needed.

Note: 2021 Jul;30(7):1349-1358

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)
2. Präventive Onkologie (C120)
3. C020 Epidemiologie von Krebs (C020)
4. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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