TY  - JOUR
AU  - Hua, Xinwei
AU  - Dai, James Y
AU  - Lindström, Sara
AU  - Harrison, Tabitha A
AU  - Lin, Yi
AU  - Alberts, Steven R
AU  - Alwers, Elizabeth
AU  - Berndt, Sonja I
AU  - Brenner, Hermann
AU  - Buchanan, Daniel D
AU  - Campbell, Peter T
AU  - Casey, Graham
AU  - Chang-Claude, Jenny
AU  - Gallinger, Steven
AU  - Giles, Graham G
AU  - Goldberg, Richard M
AU  - Gunter, Marc J
AU  - Hoffmeister, Michael
AU  - Jenkins, Mark A
AU  - Joshi, Amit D
AU  - Ma, Wenjie
AU  - Milne, Roger L
AU  - Murphy, Neil
AU  - Pai, Rish K
AU  - Sakoda, Lori C
AU  - Schoen, Robert E
AU  - Shi, Qian
AU  - Slattery, Martha L
AU  - Song, Mingyang
AU  - White, Emily
AU  - Le Marchand, Loic
AU  - Chan, Andrew T
AU  - Peters, Ulrike
AU  - Newcomb, Polly A
TI  - Genetically predicted circulating C-reactive protein concentration and colorectal cancer survival: A Mendelian randomization consortium study.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 30
IS  - 7
SN  - 1538-7755
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2021-01065
SP  - 1349-1358
PY  - 2021
N1  - 2021 Jul;30(7):1349-1358
AB  - A positive association between circulating C-reactive protein (CRP) and colorectal cancer (CRC) survival was reported in observational studies, which are susceptible to unmeasured confounding and reverse causality. We used a Mendelian randomization approach to evaluate the association between genetically-predicted CRP concentrations and CRC-specific survival.We used individual-level data for 16,918 eligible CRC cases of European ancestry from 15 studies within the International Survival Analysis of Colorectal Cancer Consortium. We calculated a genetic risk score based on 52 CRP-associated genetic variants identified from genome-wide association studies. Due to the non-collapsibility of hazard ratios from Cox proportional hazards models, we used the additive hazards model to calculate hazard differences (HD) and 95
LB  - PUB:(DE-HGF)16
C6  - pmid:33972368
DO  - DOI:10.1158/1055-9965.EPI-20-1848
UR  - https://inrepo02.dkfz.de/record/168784
ER  -