Journal Article

DKFZ-2021-01117

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Novel Biomarkers of Habitual Alcohol Intake and Associations with Risk of Pancreatic and Liver Cancers and Liver Disease Mortality.

Loftfield, E. ; Stepien, M. ; Viallon, V. ; Trijsburg, L. ; Rothwell, J. A. ; Robinot, N. ; Biessy, C. ; Bergdahl, I. A. ; Bodén, S. ; Schulze, M. B. ; Bergman, M. ; Weiderpass, E. ; Schmidt, J. A. ; Zamora-Ros, R. ; Nøst, T. H. ; Sandanger, T. M. ; Sonestedt, E. ; Ohlsson, B. ; Katzke, V.DKFZ* ; Kaaks, R.DKFZ* ; Ricceri, F. ; Tjønneland, A. ; Dahm, C. C. ; Sánchez, M.-J. ; Trichopoulou, A. ; Tumino, R. ; Chirlaque, M.-D. ; Masala, G. ; Ardanaz, E. ; Vermeulen, R. ; Brennan, P. ; Albanes, D. ; Weinstein, S. J. ; Scalbert, A. ; Freedman, N. D. ; Gunter, M. J. ; Jenab, M. ; Sinha, R. ; Keski-Rahkonen, P. ; Ferrari, P.

2021
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/jnci/djab078

Abstract: Alcohol is an established risk factor for several cancers, but modest alcohol-cancer associations may be missed due to measurement error in self-reported assessments. Biomarkers of habitual alcohol intake may provide novel insight into the relationship between alcohol and cancer risk.Untargeted metabolomics was used to identify metabolites correlated with self-reported habitual alcohol intake in a discovery dataset from the European Prospective Investigation into Cancer and Nutrition (EPIC; n = 454). Statistically significant correlations were tested in independent datasets of controls from case-control studies nested within EPIC (n = 280) and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC; n = 438) study. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations of alcohol-associated metabolites and self-reported alcohol intake with risk of pancreatic cancer, hepatocellular carcinoma (HCC), liver cancer, and liver disease mortality in the contributing studies.Two metabolites displayed a dose-response association with self-reported alcohol intake 2-hydroxy-3-methylbutyric acid and an unidentified compound. A 1-SD (log2) increase in levels of 2-hydroxy-3-methylbutyric acid was associated with risk of HCC (OR = 2.54; 95% CI = 1.51-4.27) and pancreatic cancer (OR = 1.43; 95% CI = 1.03-1.99) in EPIC and liver cancer (OR = 2.00; 95% CI = 1.44-2.77) and liver disease mortality (OR = 2.16; 95% CI = 1.63-2.86) in ATBC. Conversely, a 1-SD (log2) increase in questionnaire-derived alcohol intake was not associated with HCC or pancreatic cancer in EPIC or liver cancer in ATBC but was associated with liver disease mortality (OR = 2.19; 95% CI = 1.60-2.98) in ATBC.2-Hydroxy-3-methylbutyric acid is a candidate biomarker of habitual alcohol intake that may advance the study of alcohol and cancer risk in population-based studies.

Keyword(s): 2-hydroxy-3-methylbutyric acid ; ATBC ; EPIC ; alcohol intake ; biomarkers ; untargeted metabolomics

Note: 2021 Nov 2;113(11):1542-1550

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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