Journal Article DKFZ-2021-01151

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Impact of tobacco control policies implementation on future lung cancer incidence in Europe: An international, population-based modeling study.

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2021
Elsevier [Amsterdam]

The lancet / Regional health. Europe 4, 100074 () [10.1016/j.lanepe.2021.100074]
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Abstract: Despite recent trends in declining smoking rates, tobacco smoking remains the most preventable cause of cancer in Europe. We aimed to estimate numbers and proportions of future lung cancer cases that could be potentially prevented over a 20-year period if countries in Europe were to achieve a comprehensive implementation of tobacco control policies.Historical data from population-based cancer incidence (or mortality) was used to predict sex-specific lung cancer incidence for 30 European countries up to 2037. Hypothetical country-specific smoking prevalence that would be expected if countries would have achieved the highest-level implementation of tobacco control policies (defined by the maximum total score of the Tobacco Control Scale, TCS) was estimated by combining national prevalence data on current smoking and data on the status of implementation of key tobacco control policies. Resulting numbers and proportions of potentially preventable lung cancer cases were estimated taking into account latency periods between changes in smoking prevalence and excess cancer risks.In Europe, an estimated 1·65 million lung cancer cases (21·2%, 19·8% in men and 23·2% in women) could be prevented over a 20-year period with the highest-level implementation of tobacco control policies. Large variation was seen in European regions and countries reflecting the current level of tobacco control, with the largest potential for prevention in Western Europe (24·5%), Southern Europe (23·1%) and Eastern Europe (22·5%), and the lowest but still substantial potential for further prevention in Northern Europe (12·5%). In women, among whom lung cancer incidence is expected to increase, we estimated somewhat larger proportions of preventable lung cancer cases ranging from 9·9 to 33·9% as compared to men (8·6-28·5%). In the final year of study period (2037), these proportions even exceed 50% in women for some countries.Improved and expanded implementation of evidence-based tobacco control policies at the most comprehensive level could reduce future lung cancer incidence considerably across Europe.The study was funded by the German Cancer Aid ('Deutsche Krebshilfe'), grant number 70112097.

Keyword(s): APC, Age-period-cohort ; FCTC, Framework Convention on Tobacco Control ; ICD, International classification of diseases ; Lung cancer ; PIF, Potential impact fraction ; Potential impact fraction ; Prevention ; TCS, Tobacco Control Scale ; Tobacco control ; WHO, World Health Organization ; ci5plus, Cancer incidence in five continents

Classification:

Note: #EA:C070#

Contributing Institute(s):
  1. C070 Klinische Epidemiologie und Alternf. (C070)
  2. M050 Krebsprävention (M050)
  3. Präventive Onkologie (C120)
  4. DKTK HD zentral (HD01)
Research Program(s):
  1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021
Database coverage:
Medline ; DOAJ ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Emerging Sources Citation Index ; Fees ; SCOPUS ; Web of Science Core Collection
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 Record created 2021-05-26, last modified 2024-02-29


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