%0 Journal Article
%A Béziat, Vivien
%A Rapaport, Franck
%A Hu, Jiafen
%A Titeux, Matthias
%A Bonnet des Claustres, Mathilde
%A Bourgey, Mathieu
%A Griffin, Heather
%A Bandet, Élise
%A Ma, Cindy S
%A Sherkat, Roya
%A Rokni-Zadeh, Hassan
%A Louis, David M
%A Changi-Ashtiani, Majid
%A Delmonte, Ottavia M
%A Fukushima, Toshiaki
%A Habib, Tanwir
%A Guennoun, Andrea
%A Khan, Taushif
%A Bender, Noemi
%A Rahman, Mahbuba
%A About, Frédégonde
%A Yang, Rui
%A Rao, Geetha
%A Rouzaud, Claire
%A Li, Jingwei
%A Shearer, Debra
%A Balogh, Karla
%A Al Ali, Fatima
%A Ata, Manar
%A Dabiri, Soroosh
%A Momenilandi, Mana
%A Nammour, Justine
%A Alyanakian, Marie-Alexandra
%A Leruez-Ville, Marianne
%A Guenat, David
%A Materna, Marie
%A Marcot, Léa
%A Vladikine, Natasha
%A Soret, Christine
%A Vahidnezhad, Hassan
%A Youssefian, Leila
%A Saeidian, Amir Hossein
%A Uitto, Jouni
%A Catherinot, Émilie
%A Navabi, Shadi Sadat
%A Zarhrate, Mohammed
%A Woodley, David T
%A Jeljeli, Mohamed
%A Abraham, Thomas
%A Belkaya, Serkan
%A Lorenzo, Lazaro
%A Rosain, Jérémie
%A Bayat, Mousa
%A Lanternier, Fanny
%A Lortholary, Olivier
%A Zakavi, Faramarz
%A Gros, Philippe
%A Orth, Gérard
%A Abel, Laurent
%A Prétet, Jean-Luc
%A Fraitag, Sylvie
%A Jouanguy, Emmanuelle
%A Davis, Mark M
%A Tangye, Stuart G
%A Notarangelo, Luigi D
%A Marr, Nico
%A Waterboer, Tim
%A Langlais, David
%A Doorbar, John
%A Hovnanian, Alain
%A Christensen, Neil
%A Bossuyt, Xavier
%A Shahrooei, Mohammad
%A Casanova, Jean-Laurent
%T Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.
%J Cell
%V 184
%N 14
%@ 0092-8674
%C New York, NY
%I Elsevier
%M DKFZ-2021-01496
%P 3812-3828.e30
%D 2021
%Z 184(14):3812-3828.e30
%X We study a patient with the human papilloma virus (HPV)-2-driven 'tree-man' phenotype and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2-driven multifocal benign epithelial tumor overexpressing viral oncogenes in the epidermis basal layer. The patients are unexpectedly homozygous for a private CD28 variant. They have no detectable CD28 on their T cells, with the exception of a small contingent of revertant memory CD4+ T cells. T cell development is barely affected, and T cells respond to CD3 and CD2, but not CD28, costimulation. Although the patients do not display HPV-2- and HPV-4-reactive CD4+ T cells in vitro, they make antibodies specific for both viruses in vivo. CD28-deficient mice are susceptible to cutaneous infections with the mouse papillomavirus MmuPV1. The control of HPV-2 and HPV-4 in keratinocytes is dependent on the T cell CD28 co-activation pathway. Surprisingly, human CD28-dependent T cell responses are largely redundant for protective immunity.
%K CD28 (Other)
%K HPV (Other)
%K T cell (Other)
%K cutaneous horn (Other)
%K immunodeficiency (Other)
%K oncogene (Other)
%K papillomavirus (Other)
%K somatic reversion (Other)
%K tree man syndrome (Other)
%K wart (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34214472
%R 10.1016/j.cell.2021.06.004
%U https://inrepo02.dkfz.de/record/169689