Journal Article

DKFZ-2021-01496

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.

Béziat, V. ; Rapaport, F. ; Hu, J. ; Titeux, M. ; Bonnet des Claustres, M. ; Bourgey, M. ; Griffin, H. ; Bandet, É. ; Ma, C. S. ; Sherkat, R. ; Rokni-Zadeh, H. ; Louis, D. M. ; Changi-Ashtiani, M. ; Delmonte, O. M. ; Fukushima, T. ; Habib, T. ; Guennoun, A. ; Khan, T. ; Bender, N.DKFZ* ; Rahman, M. ; About, F. ; Yang, R. ; Rao, G. ; Rouzaud, C. ; Li, J. ; Shearer, D. ; Balogh, K. ; Al Ali, F. ; Ata, M. ; Dabiri, S. ; Momenilandi, M. ; Nammour, J. ; Alyanakian, M.-A. ; Leruez-Ville, M. ; Guenat, D. ; Materna, M. ; Marcot, L. ; Vladikine, N. ; Soret, C. ; Vahidnezhad, H. ; Youssefian, L. ; Saeidian, A. H. ; Uitto, J. ; Catherinot, É. ; Navabi, S. S. ; Zarhrate, M. ; Woodley, D. T. ; Jeljeli, M. ; Abraham, T. ; Belkaya, S. ; Lorenzo, L. ; Rosain, J. ; Bayat, M. ; Lanternier, F. ; Lortholary, O. ; Zakavi, F. ; Gros, P. ; Orth, G. ; Abel, L. ; Prétet, J.-L. ; Fraitag, S. ; Jouanguy, E. ; Davis, M. M. ; Tangye, S. G. ; Notarangelo, L. D. ; Marr, N. ; Waterboer, T.DKFZ* ; Langlais, D. ; Doorbar, J. ; Hovnanian, A. ; Christensen, N. ; Bossuyt, X. ; Shahrooei, M. ; Casanova, J.-L.

2021
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.cell.2021.06.004

Abstract: We study a patient with the human papilloma virus (HPV)-2-driven 'tree-man' phenotype and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2-driven multifocal benign epithelial tumor overexpressing viral oncogenes in the epidermis basal layer. The patients are unexpectedly homozygous for a private CD28 variant. They have no detectable CD28 on their T cells, with the exception of a small contingent of revertant memory CD4+ T cells. T cell development is barely affected, and T cells respond to CD3 and CD2, but not CD28, costimulation. Although the patients do not display HPV-2- and HPV-4-reactive CD4+ T cells in vitro, they make antibodies specific for both viruses in vivo. CD28-deficient mice are susceptible to cutaneous infections with the mouse papillomavirus MmuPV1. The control of HPV-2 and HPV-4 in keratinocytes is dependent on the T cell CD28 co-activation pathway. Surprisingly, human CD28-dependent T cell responses are largely redundant for protective immunity.

Keyword(s): CD28 ; HPV ; T cell ; cutaneous horn ; immunodeficiency ; oncogene ; papillomavirus ; somatic reversion ; tree man syndrome ; wart

Note: 184(14):3812-3828.e30

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Contributing Institute(s):

1. Infektionen und Krebs-Epidemiologie (F022)
2. Infektionen und Krebs-Epidemiologie (F020)

Research Program(s):

1. 316 - Infektionen, Entzündung und Krebs (POF4-316) (POF4-316)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 30 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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